SynthesisNeurosurgical review2025
Incidence and risk factors of hyponatremia after transsphenoidal surgery: a systematic meta-analysis.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transsphenoidal approach to sellar lesions is a mainstay technique in modern neurosurgical treatment of pituitary adenomas. One prominent complication following transsphenoidal surgery is the development of postoperative hyponatremia, frequently necessitating additional medical management and hospital readmission. However, the precise incidence and risk factors of postoperative hyponatremia remain unclear in the current literature. We conducted a systematic meta-analysis of 104 studies (31,676 patients) to clarify the incidence of postoperative hyponatremia and associated hospital readmission, as well as to summarize conflicting findings regarding significant risk factors of postoperative hyponatremia. The overall incidence of postoperative hyponatremia following transsphenoidal surgery was 13.3% [95% Confidence Interval (CI): 11.8-14.7%; 96 studies]. The rate of hospital readmission due to postoperative hyponatremia was 3.3% [95% CI: 2.7-3.9%; 33 studies]. Factors such as infundibular stalk deviation angle, plasma copeptin level, and Knosp grades served as more reliable predictors of postoperative hyponatremia. In contrast, conventional demographic and surgical parameters such as patient age, body mass index, sex, and extent of resection were not consistently identified as significant predictive factors. Secondary analyses revealed that prophylactic fluid restriction significantly reduced the incidence of postoperative hyponatremia from ~ 13.1% to ~ 4.0% (Odds Ratio 3.39 [95% CI; 2.18-5.26, Z = 5.545, P < 0.001]. This meta-analysis establishes definitive 'benchmarks' for anticipated complications after transsphenoidal surgery while highlighting important factors such as prophylactic fluid restriction protocols as a key source of inter-study variability. In addition, this study summarizes the congruence of the predictive factors thought to be influential in leading to postoperative hyponatremia, highlighting key areas of (dis)agreement.
Indexed as
Identifiers
40892282What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.