Evidence map›Paper›PMID 40892268›Full record

Trial reportUrolithiasis2025

High-power Ho:YAG lithotripsy increases subclinical renal stress: a prospective randomized KIM-1 study.

Haider Nihad Izaddin Alalam, Furkan Güldibi, Mehmet Giray Sönmez, Cemile Topçu, Selçuk Güven, Mehmet Balasar

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Urolithiasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haider Nihad Izaddin AlalamUrology Department, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. hayderal-alim@hotmail.com.ORCID http://orcid.org/0000-0001-9941-3427
Furkan GüldibiUrology Department, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Mehmet Giray SönmezUrology Department, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Cemile TopçuBiochemistry Department, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Selçuk GüvenUrology Department, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Mehmet BalasarUrology Department, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to compare the safety profile of high-power (HPL) and low-power (LPL) Holmium:YAG lasers in retrograde intrarenal surgery (RIRS), using urinary Kidney Injury Molecule-1 (KIM-1) as an early biomarker for acute kidney injury (AKI). Sixty patients with renal stones (1.5-2.5 cm) were prospectively randomized into HPL and LPL groups. Urinary KIM-1 and KIM-1/creatinine ratios were measured preoperatively and at 4 and 24 h postoperatively. Intraoperative parameters, stone-free rates (SFR), complications, and renal function (eGFR, serum creatinine) were also assessed. Intrarenal temperatures were recorded before and after lithotripsy. Operative time, SFR, complication rates, and renal function parameters were similar between groups (p > 0.05). However, KIM-1 levels were significantly higher in the HPL group at 24 h postoperatively (278.8 ± 239.6 pg/mL vs. 170.3 ± 172.9 pg/mL, p = 0.003), and the KIM-1/creatinine ratio was also elevated (5.5 ± 4.5 vs. 3.1 ± 2.0, p = 0.035). No significant differences were observed in postoperative serum creatinine or eGFR. Intraoperative renal temperatures increased slightly in the HPL group, but the difference was not statistically significant. While high-power laser lithotripsy does not adversely affect global renal function, it is associated with elevated levels of renal injury biomarkers, suggesting greater subclinical renal stress.

Indexed as

Acute Kidney InjuryHepatitis A Virus Cellular Receptor 1Kidney CalculiLasers, Solid-StateLithotripsy, LaserAdultAgedBiomarkersCreatinineFemaleHumansKidneyMaleMiddle AgedPostoperative ComplicationsProspective StudiesBiomarkersCreatinineHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1High-power laserKidney stoneKIM-1Low-power laserRetrograde intrarenal surgeryUrinary KIM-1

Identifiers

PMID40892268

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.