ArticleWorld journal of urology2025
Post-surgical outcomes in transgender women: a prospective analysis of sexual function and health-related quality of life.
Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- [Vaginoplasty to address gender incongruence].Urologie (Heidelberg, Germany) · 2026Review
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Authors and funding
5 authors.
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Abstract
purposeTo prospectively evaluate patient and clinician reported outcomes of sexual function and health-related quality of life (QOL) of transgender women preoperatively (t0), 6 months (t1), and 12 months (t2) after gender-affirming surgery (GAS) with penile inversion vaginoplasty.
methodsTransgender women undergoing two-stage GAS at our tertiary care center were included (04/2019-01/2023). Patients received a composed questionnaire including a validated questionnaire (SF-12). Clinical outcomes and adverse events were evaluated. A regression analysis was performed to identify possible risk factors for a deterioration in sexual function and QOL.
resultsFifty-three patients with an average age of 40.27 ± 14.43 years were included. Complications were mostly minor (Clavien Dindo Classification grade I/II). The depth of the neovagina postoperatively was 11.98 ± 2.19 cm and the width 3.44 ± 0.98 cm. 79.4% of patients were able to experience an orgasm 12 months postoperatively. Orgasm quality increased significantly over the measurement time points (p = 0.003). The SF-12 average physical and mental scores of our collective were similar to the German populations average scores with no significant differences between the time measurement points (p = 0.405 and p = 0.198, respectively). The mental score was always lower than the physical score. A multiple linear regression analysis showed age < 40 years to be a significant influence factor regarding the physical QOL-score (p = 0.048) and the ability to experience an orgasm (p = 0.026).
conclusionPenile inversion vaginoplasty is a safe procedure that yields favorable outcomes regarding sexual function and health-related QOL. Younger age significantly predicts improved physical QOL and the ability to experience orgasm postoperatively.
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