Evidence map›Paper›PMID 40892242›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Unraveling the vicious cycle: longitudinal analysis between financial toxicity and symptom burden in women with breast cancer.

Yi Kuang, Xiang Qi, Jiajia Qiu, Ye Liu, Sijin Guo, Ting Chen, Lichen Tang, Winnie K W So, Weijie Xing

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yi KuangIntensive Care Unit, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiang QiRory Meyers College of Nursing, New York University, New York City, New York, USA.
Jiajia QiuFudan University Shanghai Cancer Center, Shanghai, China.
Ye LiuThe First Hospital of China Medical University, Shenyang, China.
Sijin GuoXijing Hospital, The Air Force Medical University, Xi'an, China.
Ting ChenUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lichen TangFudan University Shanghai Cancer Center, Shanghai, China.
Winnie K W SoThe Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Weijie XingSchool of Nursing, Fudan University, Shanghai, China. xingweijie@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFinancial toxicity (FT) from cancer treatment significantly impacts the quality of life among breast cancer patients. The study aimed to assess the longitudinal associations between FT and symptom burden in Chinese breast cancer patients.

methodsThis prospective cohort study was conducted from November 2022 to March 2024. Participants were recruited from four Grade-A public hospitals across different areas of China using convenience sampling. FT was assessed using the Comprehensive Score for Financial Toxicity, with higher scores indicating better financial well-being. Symptom burden was measured with the BCPT (Breast Cancer Prevention Trial) Eight Symptom Scale and the Memorial Symptom Assessment Scale-Short Form Psychological Subscales, with higher scores indicating greater psychological symptom burden. Assessments were conducted at baseline (T1), 3 months (T2), 6 months (T3), and 12 months (T4) post-surgery.

resultsAmong 378 participants (all women; mean [SD] age, 48.9 [9.97] years), a moderate negative association was found between physical symptom burden and FT (r = -0.498 to -0.411) and between psychological symptom burden and FT (r = -0.493 to -0.392). Random Intercept Cross-lagged Panel Model demonstrated that FT negatively predicted the subsequent physical symptom burden (r = -0.166 to -0.122, p < 0.05). Physical symptom burden at T1 and T3 also negatively predicted the subsequent FT (r = -0.294 to -0.186, p < 0.05). Additionally, psychological symptom burden negatively predicted FT at the subsequent time point (r = -0.116 to -0.069, p < 0.05).

conclusionsThis study found vicious associations between FT and symptom burden in breast cancer patients. Future interventions addressing FT should incorporate the monitoring and management of symptom burden.

Indexed as

Breast NeoplasmsCost of IllnessFinancial StressQuality of LifeAdultChinaFemaleHumansLongitudinal StudiesMiddle AgedProspective StudiesSymptom BurdenBreast cancerFinancial toxicityLongitudinal studyRandom Intercept Cross-lagged Panel ModelSymptom burden

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.