Evidence map›Paper›PMID 40892086›Full record

ArticlePediatric radiology2025

Discordance between knee and hand-wrist bone age in adolescents: implications for skeletal maturity assessment and its association with thyroid-stimulating hormone levels.

Yuxin Sun, Zhibo Zhou, Xueqing Zheng, Hanze Du, Fengdan Wang, Shi Chen, Hui Pan

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuxin SunEight-Year Program of Clinical Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Zhibo ZhouKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Xueqing ZhengDepartment of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Hanze DuKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Fengdan WangDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Shi ChenKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. cs0083@126.com.
Hui PanKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Funding

National Key Research and Development Program of China 2022YFC3600202STI2030-MajorProjects 2021ZD0200500
6 · The paper itself

Abstract

backgroundHand-wrist radiographs may not fully reflect skeletal bone age (BA) during mid-to-late puberty. Knee magnetic resonance imaging (MRI), a non-radiative imaging technique, may provide detailed evaluation of the lower limbs.

objectiveTo validate the San Diego MRI-based knee BA atlas in a Chinese adolescent cohort presenting with growth deceleration, evaluate the concordance between knee and hand-wrist BA, and explore factors influencing potential discrepancies. MATERIALS AND

methodsThis study involved 227 adolescents. Hand-wrist BA was assessed using the Greulich and Pyle atlas with hand-wrist radiographs, and knee BA using the San Diego atlas with knee MRI. Correlations between knee BA, hand-wrist BA, and chronological age (CA) were analyzed. Discrepancies between the two sites were further evaluated for associated clinical factors.

resultsKnee BA correlated better with CA (r

conclusionKnee MRI is a reliable imaging modality for assessing skeletal maturity in adolescents with growth retardation. A moderate correlation was observed between hand-wrist and knee BA. In adolescents with elevated TSH levels, knee MRI may be preferable to hand-wrist radiographs for predicting final height, evaluating growth potential, and guiding growth hormone therapy decisions.

Indexed as

Age Determination by SkeletonHand BonesKneeMagnetic Resonance ImagingThyrotropinAdolescentChildFemaleHumansMaleReproducibility of ResultsThyrotropinAdolescentAge determination by skeletonMagnetic resonance imagingRadiographyThyrotropin

Identifiers

PMID40892086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.