Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Ocular surface homeostasis instability in acoustic neuroma: corneal nerve density reduction and blink reflex abnormalities.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Dual vision transformer with bio-inspired optimization for explainable keratoconus classification.International ophthalmology · 2026Article
- Case Report: Twisted subbasal corneal nerve fibers in a case of neurofibromatosis type 1.Frontiers in neuroscience · 2026Article
- Metaheuristic-optimized swin transformer with SHAP explainability for keratoconus classification from corneal topography maps.International ophthalmology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo assess the condition of the ocular surface and electrophysiology in patients diagnosed with acoustic neuroma.
methodsFor this prospective case-control observational study, twenty-nine patients diagnosed with acoustic neuroma and eleven healthy individuals were included. All participants underwent a comprehensive ophthalmic assessment, including assessment of corneal sensitivity, morphologic examination of cornea nerves using in vivo confocal microscopy (IVCM), and electrophysiology evaluation.
resultsIn a cohort of 29 patients diagnosed with acoustic neuroma, 48.3% (n = 14) were male, with an average age of 49.10 ± 11.82 years. Conversely, within the group of 11 healthy participants, 54.5% (n = 6) were male, with an average age of 44.64 ± 8.14 years. The ST I and TFBUT exhibited decreased values in the ipsilateral eyes of patients with acoustic neuroma compared to the contralateral eyes (ST I: 8.25 [1.00, 30.00] vs. 10.35 [1.00, 30.00], P = 0.011; TFBUT: 4.70 [2.00, 15.00] vs. 6.35 [2.00, 15.00], P = 0.029). Furthermore, the ST values of acoustic neuroma negatively correlated with Hannover classification (β: -9.14 [-18.09, -0.18], P = 0.046). In terms of blink reflex electrophysiology, the latency of R1 and R2 waves on the ipsilateral side was prolonged compared to the contralateral sides (P < 0.05).
conclusionsThis study sheds light on the ocular manifestations of acoustic neuroma with a significant reduction in ST I values and TFBUT. This can be attributed to a decrease in the density of central corneal nerve and a change in blink reflex electrophysiology with a prolonged latency of R1 & R2 waves on the ipsilateral side.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.