Evidence map›Paper›PMID 40892065›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

Cryptogenic stroke, left atrial function, and atrial fibrillation: a complex relationship.

Francesca Augusta Gabrielli, Gianluigi Bencardino, Antonio Di Renzo, Serena Abruzzese, Francesca Colò, Pasquale Alessandro Festa, Lorenzo Severo, Federico Ballacci, Gaetano Antonio Lanza, Antonella Lombardo and 2 more

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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca Augusta GabrielliCardiology Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. francescaaugusta.gabrielli@policlinicogemelli.it.
Gianluigi BencardinoCardiology Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Antonio Di RenzoCardiology Department, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni, Milan, Italy.
Serena AbruzzeseDepartment of Neuroscience, Catholic University School of Medicine, Rome, Italy.
Francesca ColòDepartment of Neuroscience, Catholic University School of Medicine, Rome, Italy.
Pasquale Alessandro FestaCardiology Department, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Lorenzo SeveroCardiology Department, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Federico BallacciCardiothoracic Department, University Hospital Santa Maria Della Misericordia, Udine, Italy.
Gaetano Antonio LanzaCardiology Department, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Antonella LombardoCardiology Department, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Gemma PelargonioCardiology Department, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Aldobrando BroccoliniDepartment of Neuroscience, Catholic University School of Medicine, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParoxysmal atrial fibrillation (AF) may underlie some embolic strokes of undetermined source (ESUS), but the widespread use of loop recorders (LRs) to detect it may not be cost-effective. This study evaluated whether assessing left atrial (LA) function by speckle tracking echocardiography (STE) could help to identify ESUS patients most likely to benefit from LR monitoring for AF detection.

methodsConsecutive ESUS patients diagnosed between 2020 and 2023, who underwent LR implantation and comprehensive echocardiographic evaluation, including STE, were enrolled. Patients were divided into two groups based on AF detection by LR over a median follow-up of 10.0 months (IQR 6.0-21.7).

resultsA total of 64 patients were included: 27 (42.2%) with AF (AF group) and 37 (57.8%) without AF (No-AF group). Compared to the No-AF group, patients in the AF group showed a significantly larger left atrial volume index (LAVi: 44.7 ± 10.8 vs. 34.4 ± 8.3 mL/m

conclusionsLAVi and LASct appear useful and reliable predictors of AF occurrence during follow-up in ESUS patients and may aid in selecting those who are most likely to benefit from LR implantation.

Indexed as

Atrial FibrillationAtrial Function, LeftHeart AtriaIschemic StrokeAgedEchocardiographyElectrocardiography, AmbulatoryFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesRisk FactorsAtrial fibrillationImplantable loop-recorderSpeckle tracking echocardiographyStroke

Identifiers

PMID40892065
PMCPMC13161340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.