Evidence map›Paper›PMID 40892010›Full record

ArticleBioinformatics (Oxford, England)2025

SBMLtoOdin and Menelmacar: interactive visualisation of systems biology models for expert and non-expert audiences.

Leonie J Lorenz, Antoine Andréoletti, Tung V N Nguyen, Henning Hermjakob, Richard G FitzJohn, Rahuman S Malik Sheriff, John A Lees

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leonie J LorenzEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Cambridge, CB10 1SD, United Kingdom.ORCID 0000-0002-1471-5782
Antoine AndréolettiEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Cambridge, CB10 1SD, United Kingdom.
Tung V N NguyenEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Cambridge, CB10 1SD, United Kingdom.ORCID 0000-0002-2876-6046
Henning HermjakobEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Cambridge, CB10 1SD, United Kingdom.ORCID 0000-0001-8479-0262
Richard G FitzJohnMRC Centre for Global Infectious Disease Analysis, Abdul Latif Jameel Institute for Disease and Emergency Analytics (JIDEA), School of Public Health, Imperial College London, London, W2 1PG, United Kingdom.ORCID 0000-0001-8888-3837
Rahuman S Malik SheriffEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Cambridge, CB10 1SD, United Kingdom.ORCID 0000-0003-0705-9809
John A LeesEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Cambridge, CB10 1SD, United Kingdom.ORCID 0000-0001-5360-1254

Funding

European Molecular Biology Laboratory, European Bioinformatics InstituteFrench Embassy in London
6 · The paper itself

Abstract

summaryComputational models in biology can increase our understanding of biological systems, be used to answer research questions, and make predictions. Accessibility and reusability of computational models is limited and often restricted to experts in programming and mathematics. This is due to the need to implement entire models and solvers from the mathematical notation models are normally presented as. Here, we present SBMLtoOdin, an R package that translates differential equation models in SBML format from the BioModels database into executable R code using the R package odin, allowing researchers to easily reuse models. We also present Menelmacar, a web-based application that provides interactive visualisations of these models by solving their differential equations in the browser. This platform allows non-experts to simulate and investigate models using an easy-to-use interface. AVAILABILITY AND IMPLEMENTATION: SBMLtoOdin is published under the open source Apache 2.0 licence at https://github.com/bacpop/SBMLtoOdin and can be installed as an R package. The code for the Menelmacar website is published under the MIT License at https://github.com/bacpop/odinviewer, and the website can be found at https://biomodels.bacpop.org/.

Indexed as

Models, BiologicalSoftwareSystems BiologyHumansUser-Computer Interface

Identifiers

PMID40892010
PMCPMC12472120

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.