Evidence map›Paper›PMID 40891966›Full record

ArticleACS chemical biology2025

Temporal and Spatial Characterization of CUL3

Phoebe H Fechtmeyer, Cameron Martinez, Johannes T-H Yeh

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Phoebe H FechtmeyerCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, United States.
Cameron MartinezCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, United States.
Johannes T-H YehCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, United States.ORCID 0000-0002-7198-038X

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
NCI NIH HHS P30 CA045508
6 · The paper itself

Abstract

Targeted protein degradation (TPD) is a promising modality that leverages the endogenous cellular protein degradation machinery to degrade selected proteins. Recently, we validated CUL3

Indexed as

Cullin ProteinsMacrocyclic CompoundsProteolysisTranscription FactorsUbiquitin-Protein LigasesHumansLigandsCullin ProteinsLigandsMacrocyclic CompoundsTranscription FactorsUbiquitin-Protein Ligases

Identifiers

PMID40891966
PMCPMC12476871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.