Evidence map›Paper›PMID 40891893›Full record

ArticleMicrobiology spectrum2025

The avermectin, emamectin benzoate, kills gram-positive bacteria and targets the cell envelope of

Rabih Ahmad, Drew Lewis, Lou Ann Verellen, Raymond Yin, Andrew Scott, Michael Fruci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rabih AhmadLondon Research and Development Centre, Agriculture and Agri-Food Canada, Ontario, Canada.
Drew LewisLondon Research and Development Centre, Agriculture and Agri-Food Canada, Ontario, Canada.
Lou Ann VerellenLondon Research and Development Centre, Agriculture and Agri-Food Canada, Ontario, Canada.
Raymond YinLondon Research and Development Centre, Agriculture and Agri-Food Canada, Ontario, Canada.
Andrew ScottLondon Research and Development Centre, Agriculture and Agri-Food Canada, Ontario, Canada.
Michael FruciLondon Research and Development Centre, Agriculture and Agri-Food Canada, Ontario, Canada.ORCID 0000-0003-0894-9440

Funding

Government of Canada J-002863
6 · The paper itself

Abstract

The avermectin family of anthelmintics is largely considered to lack antibacterial activity against gram-positive and gram-negative bacteria. Here, we screened six avermectins (ivermectin, eprinomectin, doramectin, abamectin, selamectin, and emamectin benzoate) and a structurally related milbemycin (moxidectin) for antibacterial activity against a panel of representative gram-positive and gram-negative bacteria. We report that emamectin benzoate exhibited activity against several species of gram-positive bacteria, whereas selamectin was active against

Indexed as

Anti-Bacterial AgentsBacillus subtilisCell MembraneCell WallGram-Positive BacteriaIvermectinMicrobial Sensitivity TestsAnti-Bacterial Agentsavermectinemamectin benzoateIvermectinantibacterialsavermectinBacillus subtiliscell envelope stress responseemamectin benzoatemilbemycinselamectinStaphylococcus aureus

Identifiers

PMID40891893
PMCPMC12502619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.