Evidence map›Paper›PMID 40891792›Full record

ArticleAnaesthesiology intensive therapy2025

Is general anesthesia neuroinjury-free and safe for gynecological patients' cognition? A comparison of two typical anesthesia schemes based on propofol and sevoflurane.

Włodzimierz Płotek, Artur Bekała, Jadwiga Łuczak-Wawrzyniak, Katarzyna Dudzińska-Rapczewska, Małgorzata Gasińska-Błotniak, Marcin Cybulski, Agnieszka Kubik-Komar, Elżbieta Kubera, Maciej Wilczak, Wojciech Dąbrowski

Abstract readComparative Study
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In one paragraph

Article in Anaesthesiology intensive therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Włodzimierz PłotekAnesthesiology and Intensive Therapy Clinic, University Clinical Hospital No. 4, Lublin, Poland.
Artur BekałaAnesthesiology and Intensive Care Ward, Heliodor Święcicki Gynecological & Obstetric Clinical Hospital, Poznań, Poland.
Jadwiga Łuczak-WawrzyniakAnesthesiology and Intensive Care Ward, Heliodor Święcicki Gynecological & Obstetric Clinical Hospital, Poznań, Poland.
Katarzyna Dudzińska-RapczewskaAnesthesiology and Intensive Care Ward, Heliodor Święcicki Gynecological & Obstetric Clinical Hospital, Poznań, Poland.
Małgorzata Gasińska-BłotniakAnesthesiology and Intensive Therapy Clinic, University Clinical Hospital No. 4, Lublin, Poland.
Marcin CybulskiDepartment of Clinical Psychology, Poznań University of Medical Sciences, Poznań, Poland.
Agnieszka Kubik-KomarFaculty of Production Engineering, Department of Applied Mathematics and Computer Science, University of Life Sciences in Lublin, Poland.
Elżbieta KuberaFaculty of Production Engineering, Department of Applied Mathematics and Computer Science, University of Life Sciences in Lublin, Poland.
Maciej WilczakMother and Child Health Clinic, Poznań University of Medical Sciences, Heliodor Święcicki Gynecological & Obstetric Clinical Hospital, Poznań, Poland.
Wojciech DąbrowskiFirst Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of the study was to evaluate the neurocognitive safety of two schemes of general anesthesia based on propofol or sevoflurane applied to patients undergoing laparoscopic gynecological operations, with a special focus on the patients' age, American Society of Anesthesiologists (ASA) physical status/risk category I, II, or III, and levels of neuromarkers. MATERIAL AND

methodsThe Montreal Cognitive Assessment (MoCA) was chosen for cognitive assessment. The potential neuroinjury after anesthesia and operation was assessed with a set of neuromarkers: glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), tau protein (tau), and ubiquitin C-terminal hydrolase L1 (UCH-L1). The study was conducted on a group of women with no prior neurological or psychiatric diseases.

resultsA total of 61 patients (mean age 40.57 years) were included in the study (29 patients under propofol-based anesthesia [PBA], 32 patients under sevoflurane-based anesthesia [SBA]). The groups were demographically comparable. The patients in both groups exhibited a postoperative increase in the MoCA regardless of the type of anesthesia. The NFL and UCH-L1 levels increased significantly in both groups. The GFAP levels were significantly higher in the SBA group. Neither the age nor the increase in the neuromarkers influenced the patients' cognition.

conclusionsThe types of anesthesia applied in the laparoscopic gynecological operations resulted in a cognitively safe outcome despite detectable alterations in the neuromarkers.

Indexed as

Anesthesia, GeneralAnesthetics, InhalationAnesthetics, IntravenousCognitionGynecologic Surgical ProceduresPropofolSevofluraneAdultFemaleHumansLaparoscopyMental Status and Dementia TestsMiddle AgedUbiquitin ThiolesteraseAnesthetics, InhalationAnesthetics, IntravenousPropofolSevofluraneUbiquitin Thiolesterasedelayed neurocognitive recoveryMontreal Cognitive Assessmentneuromarkerspropofolsevoflurane

Identifiers

PMID40891792
PMCPMC12793981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.