Evidence map›Paper›PMID 40891669›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor-Targeted Therapy.

Pengwen Chen, Guanghao Hu, Yuki Nakashima, Zhining Xu, Takayoshi Watanabe, Soichiro Kondo, Ervin Kovács, Horacio Cabral

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pengwen ChenDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Guanghao HuDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Yuki NakashimaDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Zhining XuInstitute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, 1117, Magyar Tudósok Körútja 2, Budapest, Hungary.
Takayoshi WatanabeDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Soichiro KondoDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Ervin KovácsDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Horacio CabralDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID 0000-0002-4030-2631

Funding

Aid for Exploratory Research 22K19541Aid for JSPS fellows 24KF0198Aid for JSPS fellows 24KJ0760Aid for Scientific Research A 23H00546AMED Seeds A A239Japan Agency for Medical Research and DevelopmentJapan Science and Technology AgencyJapan Society for the Promotion of ScienceJST-SPRING JPMJSP2108Project for Cancer Research and Therapeutic EvolutionPromotion of Joint International Research (Fostering Joint International Research (B) 21KK0197
6 · The paper itself

Abstract

Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA) therapeutics, particularly for tumor-targeted therapy. Here, we introduce a Light-Induced Transfection System (LITS) leveraging photosensitizing polymers to deliver mRNA systemically and activate its translation via light-triggered endosomal escape. This system enables localized protein expression in any irradiated tissue, allowing for spatial control of therapeutic effects. Using interleukin-2 (IL-2) as a model, we demonstrate that LITS can trigger proinflammatory cytokine levels in irradiated tumors, while inducing tolerogenic IL-2 levels in nonirradiated healthy tissues. This modulation of IL-2's pleiotropic effects provides both potent antitumor activity and reduced toxicity. Furthermore, by optimizing light exposure, LITS synergizes IL-2 efficacy by driving immunogenic cell death to eradicate lung metastasis in a breast cancer model. Our findings establish LITS as a programmable mRNA delivery platform for on-demand targeted and safe therapies.

Indexed as

Breast NeoplasmsRNA, MessengerAnimalsCell Line, TumorFemaleHumansInterleukin-2LightMicePhotosensitizing AgentsSignal TransductionTransfectionInterleukin-2Photosensitizing AgentsRNA, MessengerEndosomal escapeImmunotherapyInterleukin‐2Messenger RNAPhotosensitizer

Identifiers

PMID40891669
PMCPMC12535396

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.