ArticleMagnetic resonance in medicine2026
In vitro characterization of hemodynamics in bicuspid aortic valves: The impact of valve and ascending aortic morphologies.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Aortic Valve Phenotype Shapes Helical Flow in the Ascending Aorta: Insights from 4D Flow MRI.Annals of biomedical engineering · 2026Article
- In vitro characterization of hemodynamics in bicuspid aortic valves: The impact of valve and ascending aortic morphologies.Magnetic resonance in medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThis study investigated the effect of bicuspid aortic valve (BAV) morphology and ascending aortic curvature (AAAc) bending angles on aortic hemodynamics, focusing on transvalvular jets and secondary helical flows that contribute to systolic hemodynamic stress linked to aortic complications.
methodsUsing an MRI-compatible pulsatile flow and pressure system, 24 configurations involving six aortic valves (three Type 1 asymmetric BAVs, two Type 0 symmetric BAVs, and one tricuspid aortic valve [TAV]) across four ascending aortic morphologies-two diameters (30 mm and 40 mm) and two AAAc angles (130° and 109°)-were analyzed through four-dimensional-flow MRI measurements.
resultsThree Type 1 BAVs displayed highly deviated transvalvular jets directed toward the aortic wall on the side of the nonfused cusp. Particularly, the right-noncoronary and left-noncoronary cusp fusion phenotypes exhibited markedly eccentric secondary helical flows, thereby increasing hemodynamic stress on the ascending aortic wall. A narrower AAAc further amplified these effects by elevating jet velocity and circulation. Conversely, Type 0 BAVs and TAV were suggested to have lower hemodynamic forces, characterized by less-deviated jets and reduced secondary helical flow eccentricity. Aortic dilation, while enhancing secondary flow circulation, appeared to reduce eccentricity, suggesting a compensatory mechanism in response to altered hemodynamics.
conclusionThe combination of the position of the nonfused cusp and AAAc emerges as a critical determinant of secondary helical flow eccentricity and circulation during peak-to-late systole. The risk assessment based on these hemodynamic parameters offers a novel strategy for identifying individuals at elevated risk of future aortic events.
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