Evidence map›Paper›PMID 40891435›Full record

ArticleMagnetic resonance in medicine2026

Alternating-contrast single-shot spiral MR-ARFI with model-based displacement map reconstruction.

Saikat Sengupta, M Anthony Phipps, Li Min Chen, Charles F Caskey, William A Grissom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saikat SenguptaDepartment of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-5032-006X
M Anthony PhippsDepartment of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-1974-570X
Li Min ChenDepartment of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-9662-1925
Charles F CaskeyDepartment of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-4545-4842
William A GrissomDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3289-1827

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Translating an MR-guided focused ultrasound system for first-in-human precision neuromodulation of pain circuitsUG3NS135551 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASKEY, CHARLES F, CHEN, LI MIN · 2023 to 2023
$4.4M
Next generation transcranial ultrasound-based neuromodulation using phase shift nanoemulsionsR01MH132022 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Charles F Caskey · 2023 to 2026
$3.3M
Biophysical and Neural Basis of Focused Ultrasound StimulationRF1NS126144 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASKEY, CHARLES F, CHEN, LI MIN · 2022 to 2022
$2.7M
Biophysical and Neural Basis of Focused Ultrasound StimulationR01NS126144 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Charles F Caskey, Li Min Chen · 2025 to 2026
$1.7M
National Institute of Neurological Disorders and Stroke, National Institute of Mental Health RF1NS126144NIBIB NIH HHS T32 EB001628NIH HEAL Initiative UG3NS135551NIMH NIH HHS R01 MH132022NINDS NIH HHS R01 NS126144NINDS NIH HHS RF1 NS126144NINDS NIH HHS UG3 NS135551
6 · The paper itself

Abstract

purposeTo improve single-shot spiral MR-Acoustic Radiation Force Imaging (MR-ARFI)'s robustness to dynamic phase errors and evaluate it in non-human primates (NHPs) with a low-f-number transducer.

methodsA single-shot spiral MR-ARFI pulse sequence with 2 mm in-plane resolution and alternating displacement phase contrast was implemented to visualize the focus generated by a 128-element ultrasound transducer in the NHP brain. A model-based displacement map calculation was implemented to remove dynamic phase errors. MR-ARFI scans were acquired at pressure levels above and below FDA mechanical index (MI) limits, and reconstructed displacement maps were compared to maps generated by a 3D EPI MR-ARFI scan and a spiral MR-ARFI scan with blocked ultrasound triggering.

resultsThe proposed sequence and processing detected focal tissue displacements of 160 nm at a transcranial mechanical index of 0.96, which the 3D EPI could not detect, and with 9.7

conclusionSingle-shot spiral MR-ARFI can provide robust focus visualization in MR-guided ultrasound in the brain at MI levels well below the FDA limit.

Indexed as

BrainElasticity Imaging TechniquesImage Processing, Computer-AssistedMagnetic Resonance ImagingAlgorithmsAnimalsEcho-Planar ImagingImaging, Three-DimensionalMacaca mulattaPhantoms, ImagingTransducersfocused ultrasoundMR‐ARFIneuroimagingneuromodulationspiral

Identifiers

PMID40891435
PMCPMC12620155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.