Evidence map›Paper›PMID 40891397›Full record

ArticleMagnetic resonance in medicine2026

Accelerated water residual removal in MRS: Exploring deep learning versus fitting-based approaches.

Federico Turco, Johannes Slotboom, Milena Capiglioni

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Federico TurcoSupport Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.ORCID 0000-0002-1632-526X
Johannes SlotboomSupport Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.ORCID 0000-0001-5121-9852
Milena CapiglioniSupport Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.ORCID 0000-0003-0695-0229

Funding

H2020 Marie Skłodowska-Curie Actions 813120Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 182569Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 207997
6 · The paper itself

Abstract

purposeRemoving water residual signals from MRS spectra is crucial for accurate metabolite quantification. However, currently available algorithms are computationally intensive and time-consuming, limiting their clinical applicability. This work aims to propose and validate two novel pipelines for fast water residual removal in MRS.

methodsTwo methods for water residual removal are proposed and evaluated: DeepWatR and WaterFit. DeepWatR uses a U-Net-like architecture with an attention mechanism for skip connections. WaterFit uses Torch auto-differentiation to estimate parameters for a 7-pool Lorentzian model. The accuracy and time-efficiency of these methods were assessed using simulated and in vivo 1H brain datasets and compared with the gold standard, Hankel Lanczos singular value decomposition method (HLSVD)Pro.

resultsIn the simulated dataset, the average percentage quantification error was

conclusionWaterFit showed a superior balance of accuracy and processing speed in removing water residual from MRS data compared to DeepWatR. The proposed WaterFit implementation significantly reduces preprocessing time while maintaining metabolite fitting accuracy comparable to gold standard methods. This advancement addresses the need for efficient processing methods that can facilitate analysis and enhance the clinical utility of MRS.

Indexed as

BrainDeep LearningImage Processing, Computer-AssistedWaterAlgorithmsComputer SimulationHumansMagnetic Resonance SpectroscopyReproducibility of ResultsWater3D‐MRSIdeep learning frameworksGPU optimizationtorch auto‐differentiationwater residual removal

Identifiers

PMID40891397
PMCPMC12620168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.