Evidence map›Paper›PMID 40891390›Full record

ArticleOrthodontics & craniofacial research2025

An Artificial Intelligence System for Staging the Spheno-Occipital Synchondrosis.

Omid Halimi Milani, Lauren Mills, Amanda Nikho, Marouane Tliba, Halil Ayyildiz, Veerasathpurush Allareddy, Rashid Ansari, Ahmet Enis Cetin, Mohammed H Elnagar

Abstract read
In one paragraph

Article in Orthodontics & craniofacial research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Omid Halimi MilaniDepartment of Electrical and Computer Engineering, University of Illinois Chicago, Chicago, Illinois, USA.
Lauren MillsDepartment of Orthodontics, College of Dentistry, University of Illinois Chicago, Chicago, Illinois, USA.
Amanda NikhoDepartment of Orthodontics, College of Dentistry, University of Illinois Chicago, Chicago, Illinois, USA.
Marouane TlibaDepartment of Electrical and Computer Engineering, University of Illinois Chicago, Chicago, Illinois, USA.
Halil AyyildizDepartment of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, Illinois, USA.
Veerasathpurush AllareddyDepartment of Orthodontics, College of Dentistry, University of Illinois Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-8199-6206
Rashid AnsariDepartment of Electrical and Computer Engineering, University of Illinois Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-6477-6578
Ahmet Enis CetinDepartment of Electrical and Computer Engineering, University of Illinois Chicago, Chicago, Illinois, USA.
Mohammed H ElnagarDepartment of Orthodontics, College of Dentistry, University of Illinois Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-2332-9250

Funding

American Association of Orthodontists Foundation
6 · The paper itself

Abstract

objectiveThe aim of this study was to develop, test and validate automated interpretable deep learning algorithms for the assessment and classification of the spheno-occipital synchondrosis (SOS) fusion stages from a cone beam computed tomography (CBCT). STUDY

designThe sample consisted of 723 CBCT scans of orthodontic patients from private practices in the midwestern United States. The SOS fusion stages were classified by two orthodontists and an oral and maxillofacial radiologist. The advanced deep learning models employed consisted of ResNet, EfficientNet and ConvNeXt. Additionally, a new attention-based model, ConvNeXt + Conv Attention, was developed to enhance classification accuracy by integrating attention mechanisms for capturing subtle medical imaging features. Laslty, YOLOv11 was integrated for fully-automated region detection and segmentation.

resultsConvNeXt + Conv Attention outperformed the other models and achieved a 88.94% accuracy with manual cropping and 82.49% accuracy in a fully automated workflow.

conclusionThis study introduces a novel artificial intelligence-based pipeline that reliably automates the classification of the SOS fusion stages using advanced deep learning models, with the highest accuracy achieved by ConvNext + Conv Attention. These models enhance the efficiency, scalability and consistency of SOS staging while minimising manual intervention from the clinician, underscoring the potential for AI-driven solutions in orthodontics and clinical workflows.

Indexed as

Artificial IntelligenceCone-Beam Computed TomographyDeep LearningOccipital BoneSphenoid BoneAdolescentAlgorithmsChildFemaleHumansMale

Identifiers

PMID40891390
PMCPMC12603675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.