Evidence map›Paper›PMID 40891367›Full record

ArticleJournal of proteome research2025

Multiomic Analysis Links Neighborhood Disadvantage to Inflammatory Proteins and Tumorigenic Markers in ER+ Breast Cancer Plasma and Tumor Samples.

Hannah Heath, Ashlie Santaliz Casiano, Farizi Fazli, Hannah McGee, Margaret Wright Geise, Ekas Abrol, Oana C Danciu, Garth H Rauscher, Ayesha Zaidi, Natalie Pulliam and 8 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hannah HeathDepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, United States.
Ashlie Santaliz CasianoLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-8821-8009
Farizi FazliDepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, United States.
Hannah McGeeSchool of Molecular and Cellular Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, United States.
Margaret Wright GeiseUniversity of Illinois Cancer Center, Chicago, Illinois 60612, United States.
Ekas AbrolUniversity of Illinois Cancer Center, Chicago, Illinois 60612, United States.
Oana C DanciuUniversity of Illinois Cancer Center, Chicago, Illinois 60612, United States.
Garth H RauscherUniversity of Illinois Cancer Center, Chicago, Illinois 60612, United States.
Ayesha ZaidiDepartment of Pathology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Natalie PulliamNorthwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Elona Liko HaziziNorthwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Sarah FriedewaldNorthwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Seema KhanNorthwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
J Julie KimNorthwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
W GradisharNorthwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Jonna FrasorDepartment of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Kent F HoskinsUniversity of Illinois Cancer Center, Chicago, Illinois 60612, United States.
Zeynep Madak-ErdoganDepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0003-2607-1643

Funding

Research Education CoreU54CA202997 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PETERSON, CARYN E., PETERSON, CARYN E. · 2015 to 2024
$13.8M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Research Education CoreU54CA203000 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YANEZ, BETINA · 2015 to 2024
$12.4M
The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)U54CA202995 · NCI · NORTHEASTERN ILLINOIS UNIVERSITY · PI CIECIERSKI, CHRISTINA · 2015 to 2024
$9.5M
NCI NIH HHS U54 CA202995NCI NIH HHS U54 CA202997NCI NIH HHS U54 CA203000NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Residing in disadvantaged neighborhoods has been linked to worsened survival among Black women with estrogen receptor-positive (ER+) breast cancer (BC), yet the underlying multiomic alterations remain underexplored. To investigate associations between neighborhood deprivation and pretreatment steroid hormones, untargeted metabolites, inflammatory proteins, and tumoral gene expression in women with primary ER+ BC and cancer-free controls, pretreatment plasma was collected from ER+ BC patients (

Indexed as

Biomarkers, TumorBreast NeoplasmsReceptors, EstrogenAdultAgedCase-Control StudiesFemaleGene Expression Regulation, NeoplasticHumansInflammationMetabolomicsMiddle AgedResidence CharacteristicsBiomarkers, TumorReceptors, Estrogenarea deprivation indexbreast cancerhealth disparitiesmetabolomicsmultiomic integrationproteomicstranscriptomics

Identifiers

PMID40891367
PMCPMC12501945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.