Evidence map›Paper›PMID 40891327›Full record

Observational studyStroke2025

Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.

Jay B Lusk, Bo Liu, Emily C O'Brien, David Hasan, Gregg C Fonarow, Kevin N Sheth, Lee H Schwamm, Ying Xian, Gregory W Albers, Jeffrey L Saver and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jay B LuskDepartment of Neurology (J.B.L., E.C.O., D.H., B.M.G.), Duke University School of Medicine, Durham, NC.ORCID 0000-0002-5728-8872
Bo LiuDepartment of Statistical Science, Duke University, Durham, NC (B.L., F.L.).ORCID 0000-0002-0949-7565
Emily C O'BrienDepartment of Neurology (J.B.L., E.C.O., D.H., B.M.G.), Duke University School of Medicine, Durham, NC.ORCID 0000-0002-8257-7561
David HasanDepartment of Neurology (J.B.L., E.C.O., D.H., B.M.G.), Duke University School of Medicine, Durham, NC.ORCID 0000-0002-8335-5442
Gregg C FonarowDepartment of Medicine (G.C.F.), University of California, Los Angeles.ORCID 0000-0002-3192-8093
Kevin N ShethDepartment of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S., L.H.S.).ORCID 0000-0003-2003-5473
Lee H SchwammDepartment of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S., L.H.S.).ORCID 0000-0003-0592-9145
Ying XianDepartment of Neurology (Y.X.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-1237-1162
Gregory W AlbersDepartment of Neurology, Stanford University School of Medicine, Palo Alto, CA (G.W.A.).ORCID 0000-0003-0263-4632
Jeffrey L SaverDepartment of Neurology (J.L.S.), University of California, Los Angeles.ORCID 0000-0001-9141-2251
Fan LiObservational Research Building Interdisciplinary Therapeutic Advances (ORBIT) Hub, Duke University, Durham, NC (J.B.L., E.C.O., F.L., B.M.G.).ORCID 0000-0002-0390-3673
Brian Mac GroryDepartment of Neurology (J.B.L., E.C.O., D.H., B.M.G.), Duke University School of Medicine, Durham, NC.ORCID 0000-0003-3914-8419

Funding

Balancing Risks and Benefits of Direct Oral Anticoagulants in Older Ischemic Stroke Patients with Atrial FibrillationR01AG066672 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI XIAN, YING · 2020 to 2025
$2.6M
Antiplatelet in Stroke: Safety and Effectiveness in Seniors (ASSESS)R01AG062770 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI XIAN, YING · 2019 to 2023
$2.2M
Cardioembolism as a Mechanism of Central Retinal Artery OcclusionK23HL161426 · NHLBI · DUKE UNIVERSITY · PI Brian Mac Grory · 2022 to 2026
$951k
NHLBI NIH HHS K23 HL161426NIA NIH HHS R01 AG062770NIA NIH HHS R01 AG066672
6 · The paper itself

Abstract

backgroundThe introduction of novel therapeutics into clinical practice could impact equity in health outcomes.

methodsThis was a retrospective, observational cohort study based on the Get With The Guidelines-Stroke program of the American Heart Association. Two epochs were considered: January 2010 to December 2014 and January 2016 to December 2019. The primary exposure was the availability of endovascular thrombectomy (EVT) at the hospital level defined by the degree of implementation of EVT (>10% change from pre-2015 to post-2015) after balancing key patient and hospital characteristics with overlap weighting. The coprimary end points were (1) the difference in in-hospital mortality for patients from counties with median income >$60 000 versus <$60 000 and (2) the difference in in-hospital mortality between Black and White patients. Secondary end points were differences in in-hospital mortality by sex, insurance status, county-level poverty, and county-level educational attainment. Exploratory end points were differences in ambulatory status at hospital discharge and a composite of in-hospital mortality/discharge to hospice across the above categories.

resultsOf 173 049 patients (median age, 75 years; 53.9% female) potentially eligible for EVT, 39 196 (22.7%) received EVT (7572 [10.0% of potentially eligible patients] between 2010 and 2014 and 31 624 [32.6% of potentially eligible patients] between 2016 and 2019). From 2010 to 2014, 1565 (20.7%) of patients and from 2016 to 2019, 5158 (16.3%) who received EVT died in hospital. Implementation of EVT was associated with decreased disparities in mortality rates for patients from counties with median inflation-adjusted income >$60 000 versus <$60 000 (absolute risk difference, 3.9% [95% CI, 0.53%-7.3%]). Implementation of EVT was not associated with changes in differences in in-hospital mortality by race, sex, county poverty rates, county educational attainment, or insurance status.

conclusionsAmong patients with acute ischemic stroke who were potentially eligible for EVT, the implementation of EVT on a hospital level did not worsen health equity in any dimension (race/ethnicity, sex, or insurance status) and was associated with improvements in socioeconomic equity in acute ischemic stroke mortality.

Indexed as

Endovascular ProceduresHealth EquityIschemic StrokeStrokeThrombectomyAgedAged, 80 and overCohort StudiesFemaleHealthcare DisparitiesHospital MortalityHospitalsHumansMaleMiddle AgedRetrospective Studieshealth care economics and organizationshealth equityhealth policyischemic strokethrombectomy

Identifiers

PMID40891327
PMCPMC12433677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.