ArticleBrain and behavior2025
Anti-Apoptotic Effects of Escin on Porphyromonas gingivalis-Derived Lipopolysaccharide-Induced Injury in SH-SY5Y Cells.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Escin Attenuates Amyloid Beta 1-42-Induced Oxidative Stress, Apoptosis, and Neuroinflammation in Neuron-Like SH-SY5Y Cells.Journal of biochemical and molecular toxicology · 2026Article
- Aesculus hippocastanum Extract Exerts Neuroprotective Effects in an MPPJournal of cellular and molecular medicine · 2026Article
- Anti-Apoptotic Effects of Escin on Porphyromonas gingivalis-Derived Lipopolysaccharide-Induced Injury in SH-SY5Y Cells.Brain and behavior · 2025Article
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9 authors.
Funding
Abstract
backgroundPorphyromonas gingivalis-derived lipopolysaccharide (Pg-LPS) may be associated with the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Escin is a bioactive compound found in the horse chestnut tree (Aesculus hippocastanum). This research investigated the impact of escin on Pg-LPS-induced injury in SH-SY5Y cells.
methodsParkinson's disease model was established using SH-SY5Y neuronal cells. Cell viability was evaluated with MTT assays. Cell morphology was observed by fluorescence microscopy. Apoptosis was detected by JC-1, TUNEL, and Hoechst/propidium iodide staining, and flow cytometric analysis. The mRNA levels of BCL2 and BAX were determined by RT-PCR, and the protein levels of BCL2/BAX, cleaved Caspase 3/Caspase 3, and PARP were evaluated through Western blotting.
resultsEscin mitigated the reduction in viability of SH-SY5Y cells caused by Pg-LPS. Pg-LPS triggered apoptosis in SH-SY5Y cells, alleviated by escin dose-dependently. Furthermore, the anti-apoptotic effect of escin was reversed by a specific apoptotic inducer.
conclusionsPg-LPS leads to SH-SY5Y cells' mitochondria malfunction and programed cell death. Escin alleviated SH-SY5Y cell injury induced by Pg-LPS through its anti-apoptotic effects.
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