ArticleJournal of Korean medical science2025
Relationship Between Aortic Valve and Mitral Annular Calcification With Coronary Artery Calcification in Asymptomatic Individuals: Cross-Sectional and Longitudinal Analyses.
Article in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAortic valve calcification (AVC), mitral annular calcification (MAC), and coronary artery calcification (CAC) all share common atherosclerotic origins. However, the relationship between these entities is not fully understood.
methodsA total of 722 asymptomatic individuals who underwent health screening with serial cardiac computed tomography (CT) were retrospectively selected for analysis. AVC, MAC, and CAC were identified on CT, and the severity was quantified using Agatston units (AU). Multivariable regression models were used to identify the association between the severity of CAC and the probability of prevalent AVC and MAC, and the relation between annualized progression rates of AVC, MAC and CAC.
resultsOn initial CT, the prevalence of AVC, MAC, and CAC was 11.4%, 6.5%, and 46.3%, respectively. Increasing baseline CAC severity was associated with a higher probability of both prevalent AVC (odds ratio [OR] per 100 AU increase, 1.03; 95% confidence interval [CI], 1.02-1.04;
conclusionWe observed a close correlation between AVC, MAC, and CAC, which is in accord with their common atherosclerotic origin. However, the correlation between MAC and CAC progression but not with AVC suggests that other factors such as hemodynamics may have an important role in the further development of calcification.
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