ArticleBrain and behavior2025
The Mediation of Circulating Inflammatory Proteins in the Causal Pathway From Immune Cells to Delirium.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The Mediation of Circulating Inflammatory Proteins in the Causal Pathway From Immune Cells to Delirium.Brain and behavior · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObservational research indicates that immune cells, in conjunction with circulating inflammatory proteins, could serve two functions in the development of delirium, despite the fact that the exact mechanisms remain ambiguous. The objective of this research is to identify the specific pathways through which immune cells trigger delirium and to evaluate the possible function of circulating inflammatory proteins as intermediaries.
methodsA two-sample Mendelian randomization (MR) analysis was conducted using summary-level data from genome-wide association studies, which included 731 immune cells, 91 inflammatory proteins, and their association with delirium. The causal relationships between immune cells, inflammatory proteins, and delirium were systematically assessed through multivariable Mendelian randomization (multivariable MR). Following this, sensitivity analyses were performed using the Cochran Q test to evaluate heterogeneity, alongside MR-Egger tests to examine pleiotropy. Finally, a two-step methodology was employed to identify the inflammatory proteins that mediate the impact of immune cells on the onset of delirium.
resultsMultivariable MR revealed 14 immune cell types that exhibited a causal relationship with delirium, along with 4 inflammatory proteins associated with this condition. Through a two-step analysis, it was determined that 2 inflammatory proteins mediate the influence of 2 immune cell phenotypes on delirium. Specifically, CD25 on IgD
conclusionThis study conducted a thorough investigation into the causal relationships between immune cells and delirium, while also assessing the role of inflammatory proteins as mediators. The results aid in recognizing individuals who are at an elevated risk for experiencing delirium while also offering novel perspectives for proactive preventive measures and therapeutic strategies within clinical environments.
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