Evidence map›Paper›PMID 40891098›Full record

ArticleBrain and behavior2025

Modulation of Auditory Cortex Activity in Salicylate-Induced Tinnitus Rats via Deep Brain Stimulation of the Inferior Colliculus.

Zeinab Akbarnejad, Kasra Bagherian, Seyed Ali Noorbakhsh, Ali Fathi Jouzdani, Saeid Mahmoudian, Marjan Mirsalehi, Maryam Jafarian, Ronak Mohammadi, Alimohamad Asghari, Abdoreza Asadpour

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Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zeinab AkbarnejadENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-0822-408X
Kasra BagherianENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Seyed Ali NoorbakhshScience Beam Institute, Istanbul, Turkey.
Ali Fathi JouzdaniNeuroscience and Artificial Intelligence Research Group (NAIRG), Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Saeid MahmoudianENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-6908-7605
Marjan MirsalehiENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Maryam JafarianBrain and Spinal Cord Injury Research Centre, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ronak MohammadiNeuroscience Program and Center for Brain and Mind, The University of Western Ontario, London, Ontario, Canada.
Alimohamad AsghariENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abdoreza AsadpourSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.ORCID https://orcid.org/0000-0001-6470-9447

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTinnitus, a self-reported perceptual disorder, is currently believed to arise from maladaptive plasticity due to reduced sensory input. While deep brain stimulation (DBS) has shown promise in alleviating tinnitus-related behaviors, its effects on neuronal activity remain unclear. This study aimed to evaluate the spontaneous firing rates (SFRs) of the primary auditory cortex (A1) before and after DBS of the external cortex of the inferior colliculus (ECIC) in a rat model of tinnitus.

methodsTinnitus was induced in rats through sodium salicylate injections for 14 consecutive days, while the control group received normal saline injections over the same period. We conducted tinnitus and hearing assessments using the gap pre-pulse inhibition of the acoustic startle (GPIAS) and pre-pulse inhibition (PPI) tests. From day 14, both groups underwent DBS of the ECIC and single unit recordings from the A1.

resultsBefore ECIC stimulation, A1 neurons in rats with potential tinnitus exhibited significantly higher spontaneous activity compared to controls. Following ECIC stimulation, the SFRs in the group displaying abnormal GPIAS responses significantly decreased, and the difference between the tinnitus and control groups was no longer significant. Additionally, inter-spike interval (ISI) analysis revealed a higher frequency of short ISIs (<5 ms) in rats with potential tinnitus, which decreased after DBS, aligning with values observed in the control group.

conclusionECIC stimulation effectively modulates A1 hyperactivity, highlighting its role in tinnitus pathophysiology. These findings warrant further research into ECIC's role in tinnitus regulation, which could inform future therapeutic interventions and enhance mathematical models of tinnitus mechanisms.

Indexed as

Auditory CortexDeep Brain StimulationInferior ColliculiTinnitusAnimalsDisease Models, AnimalMaleNeuronsRatsRats, Sprague-DawleyReflex, StartleSodium SalicylateSodium Salicylateauditory cortexdeep brain electrical stimulationinferior colliculusspontaneous firing ratetinnitus

Identifiers

PMID40891098
PMCPMC12402396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.