Evidence map›Paper›PMID 40891084›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Are Grignard Reactions in Deep Eutectic Solvents Interface-Driven?

Iva Manasi, Marco Bortoli, Daniel T Bowron, Mario Campana, Oliver S Hammond, Thomas F Headen, Jake Hooton, Eva Hevia, Michele Cascella, Odile Eisenstein and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Are Grignard Reactions in Deep Eutectic Solvents Interface-Driven?Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Iva Manasi *Department of Physics, University of Bristol, Tyndall Avenue, Bristol, BS8 1TL, United Kingdom.
Marco Bortoli *Department of Chemistry and Hylleraas Centre for Quantum Molecular Sciences, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
Daniel T BowronISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Oxford, OX11 0QX, United Kingdom.
Mario CampanaISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Oxford, OX11 0QX, United Kingdom.
Oliver S HammondEuropean Spallation Source ERIC, Data Management & Software Centre, Asmussens Allé 305, Kongens Lyngby, 2800, Denmark.
Thomas F HeadenISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Oxford, OX11 0QX, United Kingdom.
Jake HootonDepartment of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AX, United Kingdom.
Eva HeviaDepartment für Chemie, Biochemie und Pharmazie, Universität Bern, Freiestrasse 3, Bern, 3012, Switzerland.
Michele CascellaDepartment of Chemistry and Hylleraas Centre for Quantum Molecular Sciences, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
Odile EisensteinDepartment of Chemistry and Hylleraas Centre for Quantum Molecular Sciences, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
Karen J EdlerDepartment of Chemistry, Centre for Analysis and Synthesis (CAS), Lund University, Lund, 221 00, Sweden.ORCID https://orcid.org/0000-0001-5822-0127

Funding

Engineering and Physical Sciences Research Council EP/S020772/1Engineering and Physical Sciences Research Council EP/S020837/1European Commission 101059679European Commission EHPC-REG-2023R02-064National Infrastructure for High-Performance Computing and Data Storage in Norway NN4654KNational Infrastructure for High-Performance Computing and Data Storage in Norway NS4654KResearch Council of Norway 262695Research Council of Norway 314009
6 · The paper itself

Abstract

Due to their high reactivity, organolithium and organomagnesium addition to ketones is usually performed under inert atmosphere at low temperature. Recent work has shown that, by dissolving the substrate in deep eutectic solvents (DES), these processes can be carried out on the benchtop, in air at room temperature. Surprisingly, the organometallic reagent, added to the DES from an organic solution, works in these conditions and gives better yields than in the standard setup. Here, we investigated acetophenone in a (1:2) choline chloride:glycerol (ChCl:Gly) DES solution by experimental liquid diffraction, neutron reflectometry, NMR, interfacial tension measurements, and by computational modelling. Our data show that this DES is a poor solvent for the ketone and promotes its accumulation at the surface of the liquid or its escape into the organic solvent. Molecular dynamics simulations of Grignard reagent i-PrMgCl in the (ChCl:Gly)/tetrahydrofuran biphasic system indicate also preference for its localisation at the interface. These results pinpoint why this combination of solvents promote the reaction, require stirring, and accounts for the lack of rapid decomposition of the organometallic reagents.

Indexed as

Biphasic systemsGreen chemistryInterfacial reactionsNon‐volatile solventsSolvophobic effect

Identifiers

PMID40891084
PMCPMC12518705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.