Evidence map›Paper›PMID 40891082›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2025

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies.

Lachlan Churchill, Anna Ignatavicius, Ajay Konuri, Jack Anderson, Natasha Taylor, Simon J G Lewis, Elie Matar

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PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lachlan ChurchillCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0003-7150-4142
Anna IgnataviciusCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0009-6558-1567
Ajay KonuriCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Jack AndersonCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0006-4967-7372
Natasha TaylorSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-3714-8290
Simon J G LewisMacquarie Medical School and Macquarie University, Centre for Parkinson's Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4093-7071
Elie MatarCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4994-0488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIsolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Time-averaged (static) and time-varying (dynamic) functional connectivity between large-scale brain networks may sensitively capture early pathophysiological changes and offer prognostic value beyond structural imaging.

objectivesTo use functional magnetic resonance imaging (fMRI) on a longitudinal iRBD cohort to assess alterations in static and dynamic functional connectivity and explore their relationship with disease conversion and regional neurotransmitter density.

methodsStatic and dynamic resting state fMRI and clinical testing were acquired from 41 iRBD participants and 38 healthy controls, with 21 iRBD participants undergoing repeated scanning.

resultsCross-sectional analysis revealed reduced static connectivity within the visual network and a shift toward a more segregated functional architecture in iRBD. Longitudinally, a further increase in segregation was observed, characterized by heightened modularity and reduced intermodular connectivity. These changes were accompanied by static connectivity disruptions in somatomotor and attentional networks, particularly pronounced in patients who converted to DLB. Regions showing the greatest connectivity decline overlapped with areas rich in cholinergic and noradrenergic transporters, suggesting early neuromodulatory dysfunction as a potential driver.

conclusionsOur findings reveal progressive functional segregation and widespread disrupted static connectivity of resting-state networks in iRBD. These results identify imaging biomarkers of disease progression, describe likely neurotransmitter associations, and support the implementation of fMRI as a sensitive tool for detecting early neurobiological signatures of synucleinopathies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

BrainLewy Body DiseaseMagnetic Resonance ImagingNerve NetParkinson DiseaseREM Sleep Behavior DisorderSynucleinopathiesAgedCross-Sectional StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedProdromal Symptomsmagnetic resonance imagingneuroimagingParkinson's diseaseREM sleep behavior disordersynucleinopathies

Identifiers

PMID40891082
PMCPMC12710112

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.