Evidence map›Paper›PMID 40891074›Full record

ReviewBrain and behavior2025

Decoding Stroke Etiology: Multi-Omics Advancements in Genetic Mechanisms and Clinical Implication.

Renxia Xiao, Mengxiao Zang, Xiaofeng Liu, Qingqing Zhu, Xiaojing Fu

Abstract readReview
In one paragraph

Review in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Renxia XiaoSchool of Nursing, Shandong Second Medical University, Weifang, Shandong, China.
Mengxiao ZangWeifang People's Hospital, Weifang, Shandong, China.
Xiaofeng LiuWeifang People's Hospital, Weifang, Shandong, China.
Qingqing ZhuWeifang People's Hospital, Weifang, Shandong, China.
Xiaojing FuSchool of Public Health, Shandong Second Medical University, Weifang, Shandong, China.ORCID https://orcid.org/0009-0001-7234-6364

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStroke has a high mortality and disability rate, yet its underlying mechanisms remain not fully understood. The occurrence of stroke is influenced by a combination of environmental factors, genetic factors, and their interaction, making its pathophysiology very intricate. FINDING: With the development of genetic technology, researchers are endeavoring to explore the genetic risks of stroke from various perspectives, including genomics, transcriptomics, proteomics, and epigenetics, beyond common risk factors such as hypertension, diabetes, and heart disease.

conclusionThese studies have produced significant findings, identifying numerous risk genes, rare variants, copy number variations, and epigenetic characteristics associated with stroke, and enhancing our understanding of stroke occurrence, progression, and prognosis, and holding great promise for advancing personalized medicine with clinical stratification and risk prediction.

Indexed as

StrokeDNA Copy Number VariationsEpigenesis, GeneticGenetic Predisposition to DiseaseGenomicsHumansMultiomicsProteomicsRisk Factors

Identifiers

PMID40891074
PMCPMC12402406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.