ArticleBipolar disorders2025
A Common Cause of ADHD and Bipolar Disorder (BD).
Article in Bipolar disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Functional Variation in RGS12 Should Not Preclude Methylphenidate Use in Bipolar Disorder with Established Mood Stabilization: Preclinical Evidence.International journal of molecular sciences · 2025Article
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5 authors.
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Abstract
objectivesBipolar and ADHD are two diseases that exhibit similar traits but at different levels of severity. Understanding this behavior can help treatment of these disorders.
methodWe hypothesize that there is a common partial genetic cause for both attention-deficit/hyperactivity disorder (ADHD) and bipolar disorders (BD), which is the reversal function of the dopamine neurotransporter DAT gate (see Figure 1) into an efflux mode. We analyze the dopamine chemistry in the neuron synapse under this assumption.
resultsThe difference between ADHD and BD phenotypes is due either to the dopamine receptor (D2R) operation or to the threshold levels of the dopamine homeostatic control and the intensity of its operation. SIGNIFICANCE: The common cause of the two disorders could explain the frequent phenomenon of ADHD symptoms preceding BD beginning and the high comorbidity between these disorders.
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