Evidence map›Paper›PMID 40890916›Full record

Trial reportPsychology and psychotherapy2026

Does remote match reality? Comparing the effectiveness of a self-help app for panic disorder and agoraphobia to face-to-face CBT.

Justine Spies, Thomas Lang, Alexander L Gerlach, Tilo Kircher, Alfons Hamm, Georg W Alpers, Thomas Fydrich, Volker Arolt, Jürgen Deckert, Andreas Ströhle and 2 more

Erratum issuedAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Psychology and psychotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Justine SpiesUniversität Hamburg, Hamburg, Germany.ORCID 0009-0002-5702-8058
Thomas LangChristoph-Dornier-Stiftung, Institut Bremen, Bremen, Germany.
Alexander L GerlachUniversität Zu Köln, Klinische Psychologie Und Psychotherapie, Köln, Germany.
Tilo KircherUniversitätsklinik für Psychiatrie und Psychotherapie, Marburg, Germany.
Alfons HammUniversität Greifswald, Greifswald, Germany.
Georg W AlpersUniversity of Mannheim, School of Social Sciences and Otto Selz Institute, Mannheim, Germany.
Thomas FydrichHumboldt-Universität zu Berlin, Berlin, Germany.
Volker AroltUniversity Hospital Münster, Münster, Germany.
Jürgen DeckertUniversitätsklinikum Würzburg, Würzburg, Germany.
Andreas StröhleCharité Universitätsmedizin Berlin, Berlin, Germany.
Hans-Ulrich WittchenIAP-AVM-Dresden GmbH, Dresden, Germany.
Sylvia Helbig-LangPTA Hamburg, Psychotherapieausbildung an der Universität Hamburg, Hamburg, Germany.

Funding

Christoph Dornier StiftungMindable Health GmbH
6 · The paper itself

Abstract

backgroundExposure-based CBT is highly effective in treating patients with panic disorder and agoraphobia; however, access to such treatments is often limited. Smartphone-based self-management apps offer a promising low-threshold treatment alternative to face-to-face therapy. Although such health apps have shown to be effective in reducing anxiety symptoms, comparisons to active treatments are still scarce. Therefore, this study compared the effectiveness of a self-help app to an established face-to-face CBT intervention for panic and agoraphobia.

methodThe present study conducts a post hoc comparison of two independent RCTs examining participants with panic disorder and/or agoraphobia. Interventions in both studies were based on the same CBT manual. Study 1 (n = 138) included face-to-face CBT; Study 2 addressed the effects of a digital self-help intervention (n = 57). Main outcomes comprised symptoms of both panic disorder and agoraphobia, depressive symptoms and agoraphobic avoidance. Data were analysed using linear mixed models in intent-to-treat and completer data sets.

resultsLinear mixed models showed that face-to-face treatment was superior to app treatment in reducing panic and agoraphobic symptoms (R DISCUSSION: Although a smartphone-based CBT intervention was effective in reducing symptoms of panic and agoraphobia, its efficacy was significantly below the effects of the same intervention delivered in face-to-face format. Thus, digital interventions might be most suitable within a stepped-care approach or to bridge waiting times for psychotherapy.

Indexed as

AgoraphobiaCognitive Behavioral TherapyMobile ApplicationsPanic DisorderSelf-ManagementAdultFemaleHumansMaleMiddle AgedSmartphoneTreatment OutcomeYoung Adultagoraphobiacognitive behavioural therapypanic disorderpost‐hoc‐comparisonsmartphone‐based

Identifiers

PMID40890916
PMCPMC12905515

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.