ArticlePrenatal diagnosis2025
The Influence of the Introduction of Fetal Anomaly Scans on Pregnancy Terminations in Cases of Upper Limb Anomalies: A Retrospective Cohort Study From 2000 to 2023.
Article in Prenatal diagnosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Genomic Landscape and Perinatal Outcomes of Fetal Polydactyly: A Retrospective Cohort Study Integrating CNV-seq and Trio-ES.Prenatal diagnosis · 2026Article
- The Influence of the Introduction of Fetal Anomaly Scans on Pregnancy Terminations in Cases of Upper Limb Anomalies: A Retrospective Cohort Study From 2000 to 2023.Prenatal diagnosis · 2025Article
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7 authors.
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Abstract
objectiveTo examine the association between the introduction of the fetal anomaly scans in the Netherlands and termination of pregnancy (TOP) in cases of prenatally detected upper limb anomalies.
methodsWe conducted a retrospective study among prenatally detected upper limb anomalies between 2000 and 2023. Anomalies were categorized as reduction defects, syndactyly, or polydactyly, and classified as isolated or non-isolated. We analyzed TOP rates across three periods (2000-2006, 2007-August 2021, September 2021-2023), including an interrupted time series (ITS) analysis to assess the impact of introducing second- and first-trimester anomaly scans (STAS, FTAS).
resultsWe included 300 pregnancies, of which 133 (44.3%) were isolated. Overall TOP rates did not differ significantly between periods, except for isolated reduction defects, where a significant increase was observed (p = 0.032). TOP rates over time did not increase for syndactyly and polydactyly. Median gestational age at diagnosis decreased across the three periods: from 20.4 to 19.4 weeks and then to 14.9 weeks. Similarly, the timing of termination of pregnancy decreased from 20.5 to 16.8 weeks and then to 15.0 weeks.
conclusionEarlier prenatal detection followed the introduction of STAS and FTAS. Despite this shift in timing, no consistent changes in termination rates were observed across the study periods. While overall TOP rates remained stable, a trend towards higher termination rates was observed for isolated reduction defects.
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