Evidence map›Paper›PMID 40890858›Full record

ArticleBMC research notes2025

Smart thin porous calcium phosphate coatings for local antibiotic delivery.

Long-Quan R V Le, Maria Carolina Lanzino, Anika Höppel, Mirjam Rech, Sofia Dembski, Andreas Killinger, Bianca Riedel, Michael Seidenstuecker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Long-Quan R V LeG.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg Medical Center, Hugstetter Straße 55, 79106, Freiburg, Germany.
Maria Carolina LanzinoInstitute for Ceramic Materials and Technologies (IKMT), University of Stuttgart, 70569, Stuttgart, Germany.
Anika HöppelDepartment for Functional Materials in Medicine and Dentistry, University of Würzburg, 97070, Würzburg, Germany.
Mirjam RechInstitute for Ceramic Materials and Technologies (IKMT), University of Stuttgart, 70569, Stuttgart, Germany.
Sofia DembskiDepartment for Functional Materials in Medicine and Dentistry, University of Würzburg, 97070, Würzburg, Germany.
Andreas KillingerInstitute for Ceramic Materials and Technologies (IKMT), University of Stuttgart, 70569, Stuttgart, Germany.
Bianca RiedelG.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg Medical Center, Hugstetter Straße 55, 79106, Freiburg, Germany.
Michael SeidenstueckerG.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg Medical Center, Hugstetter Straße 55, 79106, Freiburg, Germany. michael.seidenstuecker@uniklinik-freiburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveImplant failure after arthroplasty, primarily due to aseptic loosening or periprosthetic joint infection, remains a significant clinical problem. Bioactive ceramic coatings, such as β-tricalcium phosphate (β-TCP), enhance osseointegration and may reduce the risk of aseptic loosening. At the same time, localized antibiotic release from the implant surface represents a promising strategy to prevent early bacterial colonization. The aim of this study was to evaluate the feasibility of incorporating the heat-sensitive antibiotic vancomycin (VAN) into β-TCP coatings using high-velocity suspension flame spraying (HVSFS).

resultsWe successfully embedded VAN into β-TCP coatings by preparing suspensions containing VAN-loaded supraparticles as feedstock for the HVSFS process. High-performance liquid chromatography analysis confirmed that VAN maintained its chemical integrity during spraying, with spectra comparable to untreated controls, indicating no thermal degradation. The resulting multifunctional coatings therefore combined the osteoconductive potential of β-TCP with the antibacterial activity of VAN. These findings demonstrate that HVSFS is a viable technique for producing bioactive coatings that simultaneously promote bone integration and enable local antibiotic delivery, offering a potential strategy to mitigate both aseptic loosening and infection risks in arthroplasty.

Indexed as

Anti-Bacterial AgentsCalcium PhosphatesCoated Materials, BiocompatibleDrug Delivery SystemsVancomycinPorosityAnti-Bacterial Agentsbeta-tricalcium phosphateCalcium PhosphatesCoated Materials, BiocompatibleVancomycinCoatingsHVSFSSupraparticlesVancomycinβ-TCP

Identifiers

PMID40890858
PMCPMC12400540

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.