ArticleTropical medicine and health2025
Molecular containment of iron source inhibits larval survival of Schistosoma mansoni and egg-laying behavior of the female adult worms via ovarian atrophy.
Article in Tropical medicine and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundSchistosomiasis is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma. Currently, praziquantel is the only medication available for treating schistosomiasis. However, crucial issues regarding drug resistance, reinfection, and prevention remain unresolved. Therefore, it is indispensable to develop new antischistosomal drugs, whose mechanisms of action are distinct from that of praziquantel. This diversification in treatment is vital to promote the eradication of schistosomiasis.
methodsIn this study, to explore the untapped antischistosomal compounds against Schistosoma species, which have diverse life cycles, we initially investigated the effects of a series of phenanthroline-based compounds (PHN-X) with iron-binding affinity on the survival capacity of Schistosoma mansoni larvae and egg production by paired adult worms in vitro. Subsequently, we examined the impacts of PHN-X on the egg production and fecundity of female adult worms in vivo, following oral administration of them to mice infected with S. mansoni cercariae. Finally, we conducted a morphological analysis of the reproductive organs of the female adult worms after treating S. mansoni-infected mice with a newly identified compound with high anti-fecundity effect.
resultsThe assay for determining IC
conclusionsPHN-(OMe)
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.