Evidence map›Paper›PMID 40890844›Full record

ArticleBreast cancer research : BCR2025

Early thelarche, reproductive hormones, and MRI-based breast density: a prospective study in China.

Ying Li, Wenqing Liu, Yue Yu, Ya Wang, Liwei Zou, Deyun Liu, Ying Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying Li *Department of Maternal, Child and Adolescent Health, School of Public Health, Ministery of Education Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China.
Wenqing Liu *Department of Maternal, Child and Adolescent Health, School of Public Health, Ministery of Education Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China.
Yue YuDepartment of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Ya WangDepartment of Pediatrics, Section of Child Health, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Liwei ZouDepartment of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. zouliwei@ahmu.edu.cn.
Deyun LiuDepartment of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. 1355168128@qq.com.
Ying SunDepartment of Maternal, Child and Adolescent Health, School of Public Health, Ministery of Education Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China. yingsun@ahmu.edu.cn.

Funding

Enhancement Program for Basic and Clinical Cooperative Research of Anhui Medical University 2022xkjT035Key Scientific Research Project of Anhui Provincial Universities 2024AH040105National Natural Science Foundation of China 82173537
6 · The paper itself

Abstract

backgroundThe age of thelarche in girls has declined globally. While earlier menarche has been linked to higher breast density - a known risk factor for breast cancer - the association between earlier thelarche and breast density remains unclear.

methods114 Girls presenting with idiopathic central precocious puberty without medication (ICPP), early thelarche (ET), and normal age at thelarche (NT) were recruited from pediatric endocrine clinics of three hospitals during the year of 2020-2021 in Hefei, Anhui Province, China and were followed up for 3-5 years. Participants had their breast composition measured by MRI at 1-year post menarche. Fasting blood samples were collected at baseline and follow-up to measure of reproductive hormone concentrations.

resultsThe ET group and ICPP group exhibited significantly higher percent fibroglandular volume (%FGV: 42.1%, 52.0% ) and fibroglandular volume (FGV: 183.3 cm

conclusionIn this cohort study, earlier thelarche (even between 8.0 and 9.0 years) was associated with higher %FGV and FGV. Prolonged estrogen exposure may represent a modifiable mediator that could be targeted for breast cancer prevention strategies in girls with earlier puberty.

Indexed as

BreastBreast DensityBreast NeoplasmsPuberty, PrecociousChildChinaEstrogensFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMenarcheProspective StudiesEstrogensBreast cancer riskEarly thelarcheEstradiolInsulin-like growth factor 1Percent fibroglandular volumeProgesteronePuberty timing

Identifiers

PMID40890844
PMCPMC12403261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.