ArticleBMC musculoskeletal disorders2025
Association of volatile organic compounds with bone mineral density and osteoporosis: a cross-sectional study.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to assess the associations between volatile organic compounds (VOCs) and osteoporosis based on a national sample of US adults.
methodsA total of 991 participants from the National Health and Nutrition Examination Survey were included to investigate the relationships between VOCs and osteoporosis. Logistic regression models were employed to evaluate these associations.
resultsWe found that 2MHA, AAMA, AMCC, CEMA, CYMA, DHBMA, 3HPMA, MADA, and HPMMA were positively associated with osteoporosis. Compared to the first tertile, the odds ratios (ORs) and 95% confidence intervals (CIs) for the third tertile were as follows: 1.13 (1.02–1.28) for 2MHA, 1.12 (1.02–1.29) for AAMA, 1.25 (1.12–1.56) for AMCC, 1.20 (1.05–1.34) for CEMA, 1.35 (1.17–1.79) for CYMA, 1.15 (1.04–1.27) for DHBMA, 1.15 (1.02–1.28) for 3HPMA, 1.13 (1.01–1.27) for MADA, and 1.10 (1.02–1.32) for HPMMA. However, the associations between other VOCs and osteoporosis were not statistically significant.
conclusionsOur findings indicate that certain VOCs are associated with higher prevalence of osteoporosis. Further studies are needed to verify these findings.
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