ArticleNature metabolism2025
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation.
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Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
–field-weighted citation impact
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Who cites it
10 citing papers in PubMed.
- Unfolded Protein Response Pathways in Cancer: Mechanisms, Tumor Biology and Therapeutic Opportunities.Molecular diagnosis & therapy · 2026Review
- Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications.Molecular cancer · 2026Review
- Targeting the UPR with Small Molecules: Emerging Strategies for Immune Regulation.Molecules (Basel, Switzerland) · 2026Review
- Development of a High-Throughput UHPLC-DMS-MS/MS Method for Targeted Quantitation of Pertinent Phospholipid Classes in Colon Cancer.Molecules (Basel, Switzerland) · 2026Article
- IntratumoralFrontiers in immunology · 2026Article
- Targeting the unfolded protein response in cancer: mechanisms, small-molecule inhibitors, and translational challenges.Frontiers in immunology · 2026Review
- Bidirectional crosstalk between ER stress and lipid metabolism: From proteostasis to tumor adaptation.Cell death discovery · 2025Review
- A Novel Strategy for Enhancing Lung Cancer Immunotherapy Efficacy: Traditional Chinese Medicine Formula Shuyu Pills Enhances Anti-PD-1 Efficacy Via the "GM-ERS-Immunity" Axis.Biological procedures online · 2025Article
- The Unfolded Protein Response-Novel Mechanisms, Challenges, and Key Considerations for Therapeutic Intervention.Cancers · 2025Review
- Protein misfolding in β-cell failure.Nature reviews. Endocrinology · 2025Article
Corrections and comments
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Authors and funding
36 authors.
Olivia I Coleman *Chair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.ORCID http://orcid.org/0000-0002-4075-7820
Adam Sorbie *Chair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.ORCID http://orcid.org/0000-0002-3330-4612
Alessandra RivaChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.ORCID http://orcid.org/0000-0002-5724-7616
Miriam von SternChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.
Stephanie KuhlsChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.
Denise M SelegatoMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Luisa SiegertChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.
Isabel KeidelChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.ORCID http://orcid.org/0009-0000-9806-1087
Nikolai KöhlerLipiTUM, Chair of Experimental Bioinformatics, School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Munich, Germany.ORCID http://orcid.org/0000-0002-5103-883X
Jakob WirbelStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4073-3562
Tim KacprowskiDivision Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-5393-2413
Andreas DunkelChair of Food Chemistry and Molecular Sensory Science, School of Life Sciences, Technische Universität München, München, Germany.
Josch K PaulingLipiTUM, Chair of Experimental Bioinformatics, School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Munich, Germany.
Johannes PlaggeZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technische Universität München, Freising, Germany.
Diego Mediel-CuadraHelmholtz AI, Helmholtz Munich, Neuherberg, Germany.
Sophia J WagnerHelmholtz AI, Helmholtz Munich, Neuherberg, Germany.
Ines ChadlyChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.
Sandra BierwithChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany.
Tingying PengHelmholtz AI, Helmholtz Munich, Neuherberg, Germany.
Thomas MetzlerComparative Experimental Pathology (CEP), School of Medicine and Health, Technische Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-1620-5559
Xin LiDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Mathias HeikenwälderDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3135-2274
Clemens SchafmayerDepartment of General Surgery, University Hospital Rostock, Rostock, Germany.
Sebastian HinzDepartment of General Surgery, University Hospital Rostock, Rostock, Germany.
Christian RöderInstitute for Experimental Cancer Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Christoph RöckenDepartment of Pathology, Christian-Albrechts University, Kiel, Germany.
Michael ZimmermannMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5797-3589
Philip RosenstielInstitute of Clinical Molecular Biology, University hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0002-9692-8828
Katja SteigerComparative Experimental Pathology (CEP), School of Medicine and Health, Technische Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-7269-5433
Moritz JesinghausInstitute of Pathology, Universitätsklinikum Marburg, Baldingerstraße, Marburg, Germany.
Gerhard LiebischInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0003-4886-0811
Josef EckerZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technische Universität München, Freising, Germany.ORCID http://orcid.org/0000-0003-4799-0788
Christina SchmidtFaculty of Medicine and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3867-0881
Georg ZellerMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1429-7485
Klaus-Peter JanssenDepartment of Surgery, Klinikum rechts der Isar, Technische Universität München, München, Germany.ORCID http://orcid.org/0000-0002-4707-7887
Dirk HallerChair of Nutrition and Immunology, School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Munich, Germany. dirk.haller@tum.de.ORCID http://orcid.org/0000-0002-6977-4085
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 395357507Deutsche Forschungsgemeinschaft (German Research Foundation) 441891347
Abstract
Endoplasmic reticulum unfolded protein responses contribute to cancer development, with activating transcription factor 6 (ATF6) involved in microbiota-dependent tumorigenesis. Here we show the clinical relevance of ATF6 in individuals with early-onset and late colorectal cancer, and link ATF6 signalling to changes in lipid metabolism and intestinal microbiota. Transcriptional analysis in intestinal epithelial cells of ATF6 transgenic mice (nATF6
Indexed as
Activating Transcription Factor 6ColonColorectal NeoplasmsGastrointestinal MicrobiomeLipid MetabolismAnimalsFatty AcidsFemaleHumansMaleMiceMice, TransgenicSignal TransductionActivating Transcription Factor 6ATF6 protein, humanFatty Acids
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.