ArticleCommunications biology2025
Anatomical insights into the superior longitudinal system from integrative in- vivo and ex-vivo mapping.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Bridging Histology and Tractography: First In Vivo Visualization of Short-Range Prefrontal Connections Informed by Primate Tract-Tracing.Human brain mapping · 2026Article
- Immortalising cadaveric brain dissection using application photogrammetry.Brain structure & function · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Charting the organization of white matter (WM) pathways is essential for understanding the functioning of the human brain. This study provides a comprehensive, anatomically enhanced characterization of the superior longitudinal system (SLS) by integrating in-vivo tractography with ex-vivo dissection within the same radiological space. Using a data-driven cortex-to-cortex pairing approach leveraging gyral-sulcal macroanatomical landmarks, we reconstructed the dorsal associative connectivity of the frontal cortex in 39 healthy participants. We identified 45 SLS components, of which (i) 22 were validated and refined through ex-vivo dissection, (ii) 17 were deemed anatomically plausible despite lacking ex-vivo confirmation, and (iii) 6 were classified as anatomically implausible. The anatomical description of plausible sub-SLS templates revealed fundamental organizational principles of the system: (i) a medio-lateral and dorso-ventral hierarchy, where dorsal regions connect dorsally and ventral regions ventrally, and (ii) a depth-dependent organization, with shorter, superficial fibers linking proximal areas and longer, deeper fibers connecting distal regions. Pearson's correlation confirmed a significant positive relationship between streamline length and distance from the cortex (r = 0.689, p < 0.001). This study emphasizes the need for a distributed and integrated understanding of brain connectivity beyond classical bundle definition, and provides a robust anatomical foundation for future population-based WM atlases using bundle-specific tractography.
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Registered trials
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