Evidence map›Paper›PMID 40890476›Full record

ArticleGeroScience2026

Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging.

Maria Grazia Perino, Miguel Calvo-Rubio Barrera, Daniel R Riordon, Giulio Agnetti, Alexander Maltsev, Admira Parveen, Christopher H Morrell, Ismayil Ahmet, Khalid Chakir, Yelena S Tarasova and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Antioxidants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maria Grazia Perino *Laboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA. mariagrazia.perino@nih.gov.ORCID http://orcid.org/0000-0002-9469-8555
Miguel Calvo-Rubio Barrera *Translational Gerontology Branch, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA.
Daniel R RiordonLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Giulio AgnettiDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexander MaltsevTranslational Gerontology Branch, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA.
Admira ParveenDepartment of Biochemistry and Molecular Biology, Johns Hopkins University School of Public Health, Baltimore, MD, USA.
Christopher H MorrellLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Ismayil AhmetLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Khalid ChakirLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Yelena S TarasovaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Jia-Hua QuLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Kirill V TarasovLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Alexey E LyashkovTranslational Gerontology Branch, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA.
Yevgeniya O LukyanenkoTranslational Gerontology Branch, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA.
Hikmet KadiogluDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mark RanekDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rafael De CaboTranslational Gerontology Branch, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA.
Edward G LakattaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA.

Funding

Fondation Leducq TNE ID#673168 to GA
6 · The paper itself

Abstract

Dysregulated proteostasis is a hallmark of aging. We investigated how efficiently proteostatic adaptations to chronic cardiac cyclic-adenosine-monophosphate (cAMP)-dependent stress change with aging in mice harboring marked cardiac-specific over-expression of adenylyl cyclase VIII (TG

Indexed as

AgingCyclic AMPMyocardiumProteostasisAdaptation, PhysiologicalAnimalsAutophagyMiceMice, TransgenicProteotoxic StressCyclic AMPAgingDysregulated proteostasisProtein quality control

Identifiers

PMID40890476
PMCPMC13356016

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.