Evidence map›Paper›PMID 40890455›Full record

Articlenpj antimicrobials and resistance2025

Mitigating antimicrobial resistance by innovative solutions in AI (MARISA): a modified James Lind Alliance analysis.

William J Waldock, Hannah Thould, Leonid Chindelevitch, Nicholas J Croucher, César de la Fuente, James J Collins, Hutan Ashrafian, Ara Darzi

Abstract read
In one paragraph

Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William J WaldockInstitute of Global Health Innovation, Imperial College London, London, UK.
Hannah ThouldInstitute of Global Health Innovation, Imperial College London, London, UK.
Leonid ChindelevitchMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK.
Nicholas J CroucherMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK.
César de la FuenteMachine Biology Group, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James J CollinsDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hutan AshrafianInstitute of Global Health Innovation, Imperial College London, London, UK. hutan@ic.ac.uk.
Ara DarziInstitute of Global Health Innovation, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is a critical global health threat and artificial intelligence (AI) presents new opportunities for our response. However, research priorities at the AI-AMR intersection remain undefined. This study aimed to identify and prioritise key areas for future investigation. Using a modified James Lind Alliance approach, we conducted semi-structured interviews with eight experts in AI and AMR between February and June 2024. Analysis of 338 coded responses revealed 44 distinct themes. Major barriers included fragmented data access, integration challenges and economic disincentives. The top ten priorities identified were: Combination Therapy, Novel Therapeutics, Data Acquisition, AMR Public Health Policy, Prioritisation, Economic Resource Allocation, Diagnostics, Modelling Microbial Evolution, AMR Prediction and Surveillance. A notable limitation was the underrepresentation of data from high-burden regions, limiting the generalisability of findings. To address these gaps, we propose the novel BARDI framework: Brokered Data-sharing, AI-driven Modelling, Rapid Diagnostics, Drug Discovery and Integrated Economic Prevention.

Identifiers

PMID40890455
PMCPMC12402447

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.