ArticleHypertension research : official journal of the Japanese Society of Hypertension2025
Clinical significance of severe proteinuria in preeclampsia: a multicenter study of maternal and neonatal outcomes.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to determine the association between proteinuria severity and maternal/neonatal outcomes among preeclamptic women with hypertension with proteinuria. We retrospectively assessed 721 women at 11 institutions. All participants had singleton pregnancies and delivered at ≥22 gestational weeks. They were diagnosed with preeclampsia (excluding superimposed preeclampsia) after 20 gestational weeks and had results from a spot urine protein/creatinine ratio test at delivery. The severe proteinuria significantly increased the frequency of preterm delivery in the both women of severe and nonsevere hypertension (72.3% vs. 49.9%, 57.5% vs. 24.8%, p < 0.001, respectively). In the nonsevere hypertension and severe proteinuria group comparison with the severe hypertension and nonsevere proteinuria group, the frequency of women with pulmonary edema/pleural effusion onset was significantly higher (15.0% vs. 5.8%, p = 0.041) and the median serum albumin was significantly lower (2.6 g/dL vs. 2.8 g/dL, p < 0.001). Furthermore, the serum albumin was the laboratory findings with the highest relationship to u-P/C ratio at delivery. Women with preeclampsia with severe hypoalbuminemia had a significant high risk of developing severe proteinuria and pulmonary edema/pleural effusion at delivery than those without severe hypoalbuminemia, respectively. However, severe hypoalbuminemia was not the risk factor for severe hypertension in women with preeclampsia. Women with preeclampsia with severe proteinuria would have worse maternal outcome (pulmonary edema and/or pleural effusion induced by hypoalbuminemia) than those with severe hypertension. In conclusion, obstetricians should be aware of the risk of maternal pulmonary edema/pleural effusion in cases of preeclampsia with nonsevere hypertension with severe proteinuria.
Indexed as
Identifiers
40890418What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.