Evidence map›Paper›PMID 40890389›Full record

ArticleScientific reports2025

Distinct liver sections exhibit sex-specific gene expression patterns in Lewis rats.

Luisa Sophie Rajcsanyi, Simge Oral, Julia Borgardt, Florian Vondran, Oliver Beetz, Joanne Sambou, Selma Ugurel, Triinu Peters, Stefanie B Flohé, Andrea Kindler-Röhrborn and 3 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luisa Sophie RajcsanyiSection of Molecular Genetics in Mental Disorders, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Germany. luisa.rajcsanyi@uk-essen.de.
Simge OralDepartment of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany.
Julia BorgardtDepartment of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany.
Florian VondranReMediES, Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
Oliver BeetzReMediES, Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
Joanne SambouSection of Molecular Genetics in Mental Disorders, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Selma UgurelDepartment of Dermatology, University Hospital Essen, University of Duisburg- Essen, Essen, Germany.
Triinu PetersSection of Molecular Genetics in Mental Disorders, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Stefanie B FlohéDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Andrea Kindler-RöhrbornInstitute of Sex- and Gender-Sensitive Medicine, University Hospital Essen, Essen, Germany.
Bettina BudeusGenomics and Transcriptomics Facility, University Hospital Essen, Essen, Germany.
Arzu Oezcelik *Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany.
Anke Hinney *Section of Molecular Genetics in Mental Disorders, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex-specific differences in liver gene expression have previously been reported in humans and rodents. Clinically, female-to-male liver transplants are known to be associated with adverse post-transplantation outcomes. However, the underlying molecular mechanisms remain largely unknown. Sex-specific gene expression differences may be involved in the post-transplantation outcomes. Here, we analyse sex-specific differences in liver gene expression of Lewis rats on a genome-wide scale. In total, 543 genes exhibited a differential gene expression between male (n = 4) and female (n = 4) rats, with the largest difference found for the transcript ENSRNOG00000009273.7 (log

Indexed as

Gene Expression RegulationLiverSex CharacteristicsTranscriptomeAnimalsFemaleGene Expression ProfilingLiver TransplantationMaleRatsRats, Inbred LewSex Factors

Identifiers

PMID40890389
PMCPMC12402114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.