ArticleNature genetics2025
Inactivation of β-1,3-glucan synthase-like 5 confers broad-spectrum resistance to Plasmodiophora brassicae pathotypes in cruciferous plants.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Disabling a conserved module confers broad-spectrum resistance.Journal of integrative plant biology · 2026Article
- RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Paradoxical Immune Phenotypes and Dual-State Immune Regulators in Plants: The GSL5 Case Study.International journal of molecular sciences · 2026Review
- Loss of PMR4 callose synthase triggers jasmonic acid-dependent resistance to the clubroot disease in Arabidopsis and Brassica napus.The Plant cell · 2026Article
- BnaA07.SUC2 regulated by BnaA05.MYC2 in jasmonate pathway promotes oilseed rape susceptibility to Plasmodiophora brassicae.PLoS pathogens · 2026Article
- Effects of DifferentiationMicroorganisms · 2026Article
- Review
- Gaining extensive resistance against clubroot disease through the disruption of a susceptibility gene.Journal of integrative plant biology · 2026Article
- A Coumarin Compound Derived From Zanthoxylum avicennae Reduces the Pathogenicity of Fusarium verticillioides by Directly Binding to and Inhibiting Glycoside Hydrolase 3 Activity.Molecular plant pathology · 2026Article
- Identification of candidate genes involved in root gall formation during early infection ofFrontiers in plant science · 2026Article
- Candidate promoter-associated factors ofFrontiers in plant science · 2026Article
- Comparative analysis of the rhizosphere microbiome and transcriptome in clubroot-susceptible and resistant rapeseed (Frontiers in plant science · 2026Article
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21 authors.
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Abstract
Clubroot disease, caused by the obligate intracellular rhizarian protist Plasmodiophora brassicae, is devastating to cruciferous crops worldwide. Widespread field P. brassicae pathotypes frequently overcome the pathotype-specific resistance of modern varieties, posing a challenge for durable control of this disease. Here a genome-wide association study of 3 years of data comprising field clubroot phenotyping of 244 genome-resequenced Brassica napus accessions identified a strong association of β-1,3-glucan synthase-like 5 (GSL5) with clubroot susceptibility. GSL5 was evolutionarily conserved, and inactivation of GSL5 by genome editing in Arabidopsis, B. napus, Brassica rapa and Brassica oleracea conferred broad-spectrum, high-level resistance to P. brassicae pathotypes without yield penalties in B. napus. GSL5 inactivation derepressed the jasmonic acid-mediated immunity during P. brassicae secondary infection, and this immune repression was possibly reinforced through stabilization of GSL5 by a P. brassicae effector, facilitating clubroot susceptibility. Our study provides durable resistance resources for cruciferous clubroot disease control and insights into plant resistance against intracellular eukaryotic phytopathogens.
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