Evidence map›Paper›PMID 40890349›Full record

ArticleScientific reports2025

Serum bone turnover biomarkers in early postoperative period related to the spontaneous resolution of disc herniation.

Xu Yan, Zhanhua Ma, Su Fu, Yan Jiang, Dongzhe Li, Yongming Ning, Chao Dong, Zhengming Cao, Yongkui Wang, Chunlin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xu YanDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhanhua MaDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Su FuDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yan JiangDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Dongzhe LiDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yongming NingDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Chao DongDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhengming CaoDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yongkui WangDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China.
Chunlin ZhangDepartment of orthopaedics, the first affiliated hospital of Zhengzhou University, Zhengzhou, 450052, China. zzclin@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new way of induction surgery to obtain induced resorption of herniated nucleus pulposus (iRHNP) was recently proposed by our team, both cervical or lumbar disc herniation (CDH or LDH), when bony repair of the decompression groove simultaneously started, suggesting the possible relation to iRHNP mechanism. Since some biomarkers from peripheral blood are regarded as indicators of bone turnover, the role of circulating biomarkers for iRHNP that may reveal the mechanism remains to be determined. This study aimed to identify whether potential biomarkers changed in coincidence with the degree of iRHNP in CDH and LDH after induction surgery. A total of 73 CDH patients and 135 LDH patients, diagnosed with cervical myelopathy or lumbar stenosis accepted induction surgery, were enrolled in this retrospective study. The medical information such as T-score and volumes of CDH and LDH was monitored. The serum concentrations of five biomarkers such as osteocalcin (OCN), 25-dihydroxyvitamin D3 (25-OH-D3), β-Cross Laps, amino-terminal propeptide of type I collagen (PINP) and parathyroid hormone (PTH), and the concentration of BMP-2 were measured. As a result, the reduction in CDH and LDH volume (iRHNP) was firstly confirmed 1 week after induction surgery. The iRHNP was seen in 72.16% of CDHs and 67.81% of LDHs, with no statistical difference. In addition, the volume changes ratio in median was - 27.8% in CDHs, a greater degree than - 21.0% in LDHs. Accompanied with iRHNP occurrence, biomarkers of OCN, 25-OH-D3, PINP and PTH were significantly down-regulated while β-Cross Laps was significantly up-regulated in circulation. Correlation ships between the osteoporosis and iRHNP degree were identified. Meanwhile, the biomarkers of pre-operative circuiting levels of OCN and PINP were reflective to the degree of iRHNP. In conclusion, we found that T-score/osteoporosis was linked to iRHNP whilst serum biomarkers were predictive of the change degrees of disc herniation volume in both cervical and lumbar spine. This study suggested the iRHNP mechanism related to the circulating biomarkers in early postoperative period reflective for bone metabolism.

Indexed as

BiomarkersBone RemodelingIntervertebral Disc DisplacementAdultAgedFemaleHumansLumbar VertebraeMaleMiddle AgedOsteocalcinPeptide FragmentsPostoperative PeriodRetrospective StudiesBiomarkersOsteocalcinPeptide FragmentsAmino-terminal propeptideCervical disc herniationLumbar disc herniationOsteocalcinResorption of disc herniation

Identifiers

PMID40890349
PMCPMC12402110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.