ArticleNature aging2025
REV-ERBα regulates brain NAD
Abstract read
In one paragraph
Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- REV-ERB-Mediated Regulation of Neural Functional Mechanisms by Phytochemicals in the Circadian System.Nutrients · 2026Review
- Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer's Disease: Mechanisms and Therapeutic Restoration.Journal of molecular neuroscience : MN · 2026Review
- The biological clock in parkinson's disease: mechanisms and chronotherapy.NPJ Parkinson's disease · 2026Review
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation.Journal of virology · 2026Article
- SIRT1 deacetylates GAPDH to drive microglial glycolysis and neuroinflammation.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Jiyeon LeeDepartment of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. jylee8764@gmail.com.ORCID http://orcid.org/0000-0002-6774-2397
Ryeonghwa KangDepartment of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Sohui ParkDepartment of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Ibrahim O SaliuDepartment of Genetics and Department of Neurology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6182-5992
Minsoo SonDepartment of Biochemistry and Molecular Biophysics, Mass Spectrometry Technology Access Center (MTAC), Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8531-0320
Jaymie R VoorheesCenter for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.
Julie M DimitryDepartment of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Elsa I QuillinDepartment of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0009-0003-4652-1426
Lauren N WoodieInstitute for Diabetes, Obesity, and Metabolism and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Brian V LanannaDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Li GanHelen and Robert Appel Alzheimer Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4600-275X
Young-Ah GooDepartment of Biochemistry and Molecular Biophysics, Mass Spectrometry Technology Access Center (MTAC), Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.
Guoyan ZhaoDepartment of Genetics and Department of Neurology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5615-6774
Mitchell A LazarInstitute for Diabetes, Obesity, and Metabolism and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8653-1280
Thomas P BurrisUF Genetics Institute and Department Of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Erik S MusiekDepartment of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. musieke@wustl.edu.ORCID http://orcid.org/0000-0002-8873-0360
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MProject 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6MREV-ERB Nuclear Receptors in Circadian Rhythm and MetabolismR01DK045586 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1992 to 2026
$12.0MExpanding insights into FTD disease mechanismsR35NS097273 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2017 to 2024
$10.6MROLE OF GLIAL CIRCADIAN CLOCK DYSFUNCTION IN THE PATHOGENESIS OF ALZHEIMER'S DISEASER01AG054517 · NIA · WASHINGTON UNIVERSITY · PI Erik Steven Musiek · 2017 to 2026
$4.5MNovel genetic modifiers of C9orf72 and Tau toxicityRF1AG062077 · NIA · MAYO CLINIC ARIZONA · PI FRYER, JOHN DAVID, PETRUCELLI, LEONARD · 2019 to 2019
$4.0MNuclear Pore Complex and as a Contributor to Tau Associated DementiaRF1AG062171 · NIA · JOHNS HOPKINS UNIVERSITY · PI PETRUCELLI, LEONARD, ROTHSTEIN, JEFFREY D · 2019 to 2019
$3.8MSleep and Circadian Rhythms in Alzheimer Disease: Potential bi-directional relationship with tauRF1AG061776 · NIA · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M., JU, YO-EL S · 2019 to 2019
$3.7MRole of REV-ERB Proteins in Neuroinflammation and Alzheimer's DiseaseR01AG063743 · NIA · WASHINGTON UNIVERSITY · PI Erik Steven Musiek, Thomas Papouin · 2020 to 2026
$2.6MEvaluating novel transcription factors in regulating astrocyte identity, reactivity, and their roles in neurodegenerative disease pathogenesisR21AG089851 · NIA · WASHINGTON UNIVERSITY · PI MUSIEK, ERIK STEVEN, ZHAO, GUOYAN · 2024 to 2024
$428kNational Research Foundation of Korea (NRF) RS-2019-NR040055NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIA NIH HHS R01 AG054517NIA NIH HHS R01 AG063743NIA NIH HHS R21 AG089851NIA NIH HHS RF1 AG061776NIA NIH HHS RF1 AG062077NIA NIH HHS RF1 AG062171NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK045586NINDS NIH HHS P01 NS084974NINDS NIH HHS R35 NS097273U.S. Department of Health & Human Services | National Institutes of Health (NIH) P01NS084974-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK45586U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35NS097273U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1AG062077U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1AG062171U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG063743U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) RF1AG061776
Abstract
Nicotinamide adenine dinucleotide (NAD
Indexed as
ADP-ribosyl Cyclase 1BrainNADNuclear Receptor Subfamily 1, Group D, Member 1TauopathiesAnimalsAstrocytesCytokinesMaleMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutNicotinamide PhosphoribosyltransferaseADP-ribosyl Cyclase 1Cd38 protein, mouseCytokinesMembrane GlycoproteinsNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseNr1d1 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.