Evidence map›Paper›PMID 40890331›Full record

ArticleScientific reports2025

Identification of sensory fiber types in mouse temporomandibular joint tissues.

Jessie J Alfaro, Exing Wang, R. E.-JOIN Consortium Investigators, Armen N Akopian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jessie J AlfaroIntegrated Biomedical Sciences (IBMS) Program, The School of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, 78229, USA.
Exing WangDepartment of Cell Systems and Anatomy, The School of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, 78229, USA.
R. E.-JOIN Consortium Investigators
Armen N AkopianIntegrated Biomedical Sciences (IBMS) Program, The School of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, 78229, USA. Akopian@UTHSCSA.edu.

Funding

Institutional Research Training GrantT32DE014318 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kenneth M Hargreaves · 2002 to 2026
$12.1M
Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male, female and aged mice, primates, and humans with and without TMJ disorders (TMJD)..UC2AR082195 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ARMEN N AKOPIAN, LINDSEY J MACPHERSON · 2022 to 2026
$8.4M
LIGHT and Lymphotoxin targeting for the treatment of chronic orofacial pain conditionsR01DE029187 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N, RUPAREL, SHIVANI B · 2019 to 2021
$3.8M
NIAMS NIH HHS AR082195NIAMS NIH HHS UC2 AR082195NIDCR NIH HHS DE014318NIDCR NIH HHS R01 DE029187NIDCR NIH HHS T32 DE014318
6 · The paper itself

Abstract

Temporomandibular joint (TMJ) disorders (TMJDs) are linked to heightened nerve sensitivity in TMJ tissues. To set the groundwork for investigating the mechanisms governing this increased responsiveness, this study aimed to identify the types of nerves in the retrodiscal tissue (retrodisc), anterior disc, and joint capsule of mouse TMJ using immunohistochemistry (IHC) and reporter mice. The pan-sensory neuronal marker pgp9.5 revealed no nerves in the articular disc but identified approximately 70% unmyelinated and 30% myelinated fibers in other TMJ tissues. Nearly all sensory fibers in the joint capsule and anterior disc were CGRP

Indexed as

Sensory Receptor CellsTemporomandibular JointAnimalsCalcitonin Gene-Related PeptideImmunohistochemistryMaleMiceMice, Inbred C57BLNerve FibersReceptors, Serotonin, 5-HT3Temporomandibular Joint DisordersCalcitonin Gene-Related PeptideReceptors, Serotonin, 5-HT3Anterior discArticular discBlood vesselsJoint capsulePeptidergicRetrodiscal tissueSensory neuronsSynoviumTemporomandibular joint (TMJ)

Identifiers

PMID40890331
PMCPMC12402272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.