Evidence map›Paper›PMID 40890327›Full record

ArticleDrug delivery and translational research2026

Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson's disease treatment by intranasal administration.

Adriana Trapani, Annalucia Carbone, Sante Di Gioia, Giuseppe Fracchiolla, Piera Soccio, Filippo Maria Perna, Andrea Francesca Quivelli, Gian Paolo Suranna, Roberto Grisorio, Chiara Lo Porto and 3 more

Abstract read
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Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adriana TrapaniDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona, 4-70125, Bari, Italy. adriana.trapani@uniba.it.
Annalucia CarboneDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.
Sante Di GioiaDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.
Giuseppe FracchiollaDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona, 4-70125, Bari, Italy.
Piera SoccioDepartment of Medical and Surgical Sciences, University of Foggia, 71122, Foggia, Italy.
Filippo Maria PernaDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona, 4-70125, Bari, Italy.
Andrea Francesca QuivelliDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona, 4-70125, Bari, Italy.
Gian Paolo SurannaDepartment of Civil, Environmental, Land, Building Engineering and Chemistry (DICATECh), Bari Polytechnic, E. Orabona Street,4, I-70125, Bari, Italy.
Roberto GrisorioDepartment of Civil, Environmental, Land, Building Engineering and Chemistry (DICATECh), Bari Polytechnic, E. Orabona Street,4, I-70125, Bari, Italy.
Chiara Lo PortoDepartment of Civil, Environmental, Land, Building Engineering and Chemistry (DICATECh), Bari Polytechnic, E. Orabona Street,4, I-70125, Bari, Italy.
Daniele ConelliDepartment of Civil, Environmental, Land, Building Engineering and Chemistry (DICATECh), Bari Polytechnic, E. Orabona Street,4, I-70125, Bari, Italy.
Giuditta ColangeloDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona, 4-70125, Bari, Italy.
Massimo ConeseDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main aim of this work was to synthesize new chitosan amphiphilic derivatives able to self-assembly encapsulating substances acting at different target sites implicated in Parkinson disease (PD). For this purpose, O-carboxymethyl-chitosan (O-CMCS) was grafted with dopamine (DA) exploiting a carbodiimide mediated coupling reaction using different polymer/DA weight ratios. The structural characterization of the resulting O-CMCS-g-DA conjugates was carried out by spectral (i.e., ì FT-IR,

Indexed as

AntioxidantsAntiparkinson AgentsChitosanDopamineParkinson DiseaseQuercetinAdministration, IntranasalDrug LiberationHumansMicellesNanomedicineAntioxidantsAntiparkinson AgentsChitosanDopamineMicellesO-carboxymethylchitosanQuercetin

Identifiers

PMID40890327
PMCPMC13538208

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.