ArticleNature chemistry2025
Head-tail carboboration of multisubstituted alkenes enabled by chain recognition.
Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Resolving Chemically InequivalentJACS Au · 2026Article
- Programmable alkene skeleton construction via switchable radical and organometallic sorting.Nature chemistry · 2026Article
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precision in site-selective functionalization of molecules bearing multiple potentially reactive positions is a longstanding challenge in organic synthesis. Although migratory difunctionalization offers a powerful strategy for programmed functional group installation along carbon chains, its implementation with multisubstituted alkenes has been impeded by the increased complexity of site-selectivity. Here we report a head-tail carboboration of multisubstituted alkenes with exceptional site-selectivity, enabled by ligand steric exclusion in a nickel-catalysed chain-walking system. This catalytic system enables selective migratory transformations of tertiary alkyl-metal intermediates across a range of thermodynamically and kinetically accessible reaction site combinations. The importance of this study is evident in not only its capacity to efficiently couple structurally diverse carbon electrophiles with complex substrates, including natural terpenes, but also its contribution to streamlining the synthesis of natural products and materials.
Identifiers
40890274What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.