Evidence map›Paper›PMID 40890243›Full record

ArticleScientific reports2025

MAIA platform for routine clinical testing: an artificial intelligence embryo selection tool developed to assist embryologists.

Mariana Nicolielo, Catherine Kuhn Jacobs, Bruna Lourenço, Murilo Costa Maffeis, Dóris Spinosa Chéles, Matheus Búbola Duarte, Bruno Araújo Mendes, Vinícius Casado Moraes, Maurício Barbour Chehin, José Roberto Alegretti and 4 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mariana NicolieloEmbryology Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
Catherine Kuhn JacobsEmbryology Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
Bruna LourençoEmbryology Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
Murilo Costa MaffeisLaboratory of Applied Mathematics, Department of Biological Sciences, São Paulo State University (UNESP), Assis, SP, Brazil.
Dóris Spinosa ChélesResearch and Development Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
Matheus Búbola DuarteLaboratory of Applied Mathematics, Department of Biological Sciences, São Paulo State University (UNESP), Assis, SP, Brazil.
Bruno Araújo MendesLaboratory of Applied Mathematics, Department of Biological Sciences, São Paulo State University (UNESP), Assis, SP, Brazil.
Vinícius Casado MoraesLaboratory of Applied Mathematics, Department of Biological Sciences, São Paulo State University (UNESP), Assis, SP, Brazil.
Maurício Barbour ChehinResearch and Development Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
José Roberto AlegrettiEmbryology Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
Eduardo Leme Alves da MottaClinical Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
Aline Rodrigues LorenzonResearch and Development Department, Huntington Reproductive Medicine-Eugin Group, São Paulo, SP, Brazil.
Marcelo Fábio Gouveia NogueiraLaboratory of Embryonic Micromanipulation, Department of Biological Sciences, São Paulo State University (UNESP), Assis, SP, Brazil.
José Celso RochaLaboratory of Applied Mathematics, Department of Biological Sciences, São Paulo State University (UNESP), Assis, SP, Brazil. jose.celso@unesp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need to reduce the number of embryos transferred in assisted reproductive care to prevent multiple gestations has led to a stronger emphasis on selecting embryos with the highest morphological quality. Although this evaluation has traditionally been performed by trained embryologists, the increasing use of time-lapse incubators has introduced a greater volume of data and subjectivity in decision-making. Artificial intelligence (AI)-based tools can support embryologists by offering objective, standardized embryo assessments.In Brazil, like other countries, where imported embryo selection technologies may not account for local demographic and ethnic profiles, an AI model - Morphological Artificial Intelligence Assistance (MAIA) - was developed through a collaboration between a university and a private fertility clinic in São Paulo. The model was trained using 1,015 embryo images and prospectively tested in a clinical setting on 200 single embryo transfers. In clinical testing, MAIA achieved an overall accuracy of 66.5%. In elective embryo transfers, where there were more than one embryo eligible for transfer, MAIA achieved 70.1% accuracy for predicting clinical pregnancy. Designed with a user-friendly interface tailored by embryologists, MAIA provides real-time embryo evaluations to support decision-making in routine care.

Indexed as

Artificial IntelligenceEmbryologyEmbryo, MammalianEmbryo TransferAdultBrazilFemaleFertilization in VitroHumansPregnancy

Identifiers

PMID40890243
PMCPMC12402190

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.