ArticleNature communications2025
Towards ultra-sensitive and rapid near-source wastewater-based epidemiology.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sensitive and quantitative biosensing technique based on NV centres-doped nanodiamonds applied to lateral flow assays.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Wastewater-based epidemiology is emerging as a powerful early-warning public health surveillance tool. However, gold-standard PCR necessitates transporting samples to laboratories, with significant reporting delays (24-72 h), prompting growing interest in rapid, near-source tests for resource-limited settings. Research has focused on gold nanoparticle dipsticks, but these typically lack sensitivity in wastewater. Herein, we explore two complementary nanomaterial based approaches, using SARS-CoV-2 as an exemplar: 1) visually-read carbon black dipsticks; 2) spin-enhanced fluorescent nanodiamond dipsticks, exploiting selective separation from background autofluorescence. The assay provides a 2-hour turnaround from sample preparation to result with minimal equipment and achieves a limit of detection down to 7 copies per assay. A pilot study with samples from the Welsh National WBE programme finds 80% sensitivity and 100% specificity for carbon black, and 100% sensitivity, specificity for nanodiamonds. A proof-of-concept lab-in-a-suitcase nanodiamond assay tests raw, unprocessed wastewater samples. These findings lay the foundations for near-source WBE early-warning quantum sensors in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.