ArticleACS applied materials & interfaces2025
Macrophage-T Cell Physical Interaction Modulates IFN-γ Secretion.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Macrophages and T cells communicate under homeostatic and pathological conditions. Previous studies elucidated biochemical crosstalk between macrophages and T cells. However, recent technological advances in multiplex tissue imaging reveal that these cells are often located proximally. Notably, recent clinical studies link the proximity of macrophages and T cells to cancer outcomes. These observations suggest that physical contact between the two cell types might influence their phenotype and activity. However, systematic investigations of the potential role of physical contact between these cells are lacking. To address this gap, we developed three-dimensional (3D) coculture assays to study the potential role of physical contact between naïve macrophages and activated CD8
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