ArticleJournal of cutaneous pathology2025
Eccrine Coil Elastosis: A New Dermatopathological Feature Associated With Prediabetes and Diabetes.
Article in Journal of cutaneous pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Eccrine Coil Elastosis: A New Dermatopathological Feature Associated With Prediabetes and Diabetes.Journal of cutaneous pathology · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of diabetes mellitus continues to rise. Cutaneous histological manifestations of diabetes include microangiopathy and atherosclerosis. No morphological alterations of sweat glands have been reported. However, eccrine coil elastosis has been observed in basal cell carcinoma biopsies of a patient with metabolic syndrome, a condition that may provoke elastin glycosylation and degradation.
methodsWe conducted a retrospective study analyzing the associations between eccrine coil elastosis and well-established cardiovascular and metabolic risk factors in 245 patients with skin biopsies. The type (stretching, thickening, waving, multilamellation and fragmentation) and extent of eccrine coil elastosis were assessed. In doubtful cases, confirmation was achieved through lysozyme immunostaining.
resultsThe presence of waving, multilamellation, and/or thickening in at least one eccrine coil was independently associated with diabetes or prediabetes. Associations were also found with cardiovascular complications, age, and actinic damage, but not with hypertension, dyslipidemia, smoking, or overweight.
conclusionsAlthough eccrine coil elastosis is not restricted to patients with prediabetes and diabetes, it is much more prevalent and appears earlier in patients with these two conditions. Detecting it in skin biopsies obtained for other reasons in patients with an unknown glycemic status may serve as a potential histologic clue warranting further metabolic evaluation.
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