Evidence map›Paper›PMID 40889625›Full record

ArticleAmerican journal of ophthalmology2025

Importance of Screening for Contrast Sensitivity, Falls, and Mobility Limitations in Older Adults With Maculopathy.

Catherine P Agathos, Natela M Shanidze, Donald C Fletcher

Abstract read
In one paragraph

Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Recent Developments in Research to Make the World Better for People with Low Vision.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Catherine P AgathosFrom the Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA. Electronic address: cagathos@ski.org.
Natela M ShanidzeFrom the Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA.
Donald C FletcherFrom the Smith-Kettlewell Eye Research Institute, San Francisco, CA, USA.

Funding

Oculomotor Demands for Target Stabilization without Central VisionR01EY036172 · NEI · SMITH-KETTLEWELL EYE RESEARCH INSTITUTE · PI Natela M. Shanidze · 2024 to 2026
$1.5M
Postdoctoral Training in Vision ResearchT32EY025201 · NEI · SMITH-KETTLEWELL EYE RESEARCH INSTITUTE · PI Preeti Verghese · 2016 to 2026
$1.2M
ACL HHS 90REGE0018NEI NIH HHS R01 EY036172NEI NIH HHS T32 EY025201
6 · The paper itself

Abstract

objectiveAssess the potential value of adding questions on falls/balance difficulties due to vision loss and testing contrast sensitivity (CS) in patients with maculopathy (mainly age-related macular degeneration, AMD) to help guide referral for mobility rehabilitation.

designCross-sectional study.

participantsA total of 125 patients over 55 years old with binocular maculopathy and intact peripheral vision presenting for a low vision rehabilitation consultation.

methodsPatients were asked questions regarding difficulties with their balance and mobility, including the 9-item Glaucoma Activity Limitation questionnaire (GAL-9). For analysis, patients were grouped by visual impairment severity using better-eye visual acuity (VA) and binocular CS.

main outcome measuresVisual function, self-reported balance and mobility difficulties, falls history, and rehabilitation referrals were examined across visual impairment severity groups.

resultsTotal 52% of patients reported balance or gait difficulties and 36% attributed mobility limitations to vision loss. Increasing vision deficit severity related to greater mobility concerns (>50% of patients in the severe categories rated difficulty as 3/5 or higher) and higher referral rates. Scores on the GAL-9 increased with greater vision loss and were predicted by CS, female sex, larger relative scotomata and falls history (R

conclusionsMobility limitations and falls affect a substantial proportion of AMD patients yet may go undiscussed in eye clinics. Incorporating screening questions and explicit discussion of mobility difficulties in clinical practice in maculopathy can help elucidate patient mobility limitations. Realization of these limitations is the prerequisite to initiate appropriate referrals to low vision and mobility specialists to improve mobility and manage falls risk. Clinical practice may also benefit from assessment of CS as this is a better indicator of difficulties in daily living. Our results, along with prior literature, underscore the need to recognize the role of central vision loss, and vision loss more broadly, in mobility decline. Thus, a central vision loss-specific mobility questionnaire may be needed to facilitate patient screening in the future.

Indexed as

Accidental FallsContrast SensitivityMacular DegenerationMobility LimitationVision, LowVision ScreeningAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedPostural BalanceSurveys and QuestionnairesVision, Binocular

Identifiers

PMID40889625
PMCPMC12462652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.