Evidence map›Paper›PMID 40889547›Full record

ArticleNeuroscience letters2025

Directional flow of brain connections and neurodevelopmental outcomes in healthy full-term newborns.

Venkata Chaitanya Chirumamilla, Sarah B Mulkey, Tayyba Anwar, Robin Baker, G Larry Maxwell, Josepheen De Asis-Cruz, Kushal Kapse, Catherine Limperopoulos, Adre du Plessis, R B Govindan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Venkata Chaitanya ChirumamillaThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States.
Sarah B MulkeyThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Tayyba AnwarDepartment of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States; Department of Neurology, Children's National Hospital, Washington, DC, United States.
Robin BakerInova Women's and Children's Hospital, Fairfax, VA, United States; Fairfax Neonatal Associates, Fairfax, VA, United States.
G Larry MaxwellInova Women's and Children's Hospital, Fairfax, VA, United States.
Josepheen De Asis-CruzDeveloping Brain Institute, Children's National Hospital, Washington, DC, United States.
Kushal KapseDeveloping Brain Institute, Children's National Hospital, Washington, DC, United States.
Catherine LimperopoulosThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States; Developing Brain Institute, Children's National Hospital, Washington, DC, United States; Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, United States.
Adre du PlessisThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
R B GovindanThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States. Electronic address: rgovinda@childrensnational.org.

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876
6 · The paper itself

Abstract

objectiveWe examined whether directional flow among brain hubs in healthy-term infants is associated with neurodevelopmental outcomes at two years of age.

methodsHigh-density electroencephalography (EEG) was collected within 72 h after birth. Neurodevelopmental outcomes (cognitive, language, and motor scores) were measured using Bayley Scales of Infant Development-III (BSID-III) at two years. Source signals were extracted from the hubs, and directed information flow from hub was calculated using partial directed coherence method in delta band. The relationship between information flow and BSID-III scores was assessed using stepwise regression.

resultsForty-seven newborns had EEG and BSID-III scores. Efferent flow from the left amygdala (t-statistic = -2.97, p = 0.027), right amygdala (t-statistic = -2.15, p = 0.03), and right caudate nucleus (t-statistic = -2.16, p = 0.036) were negatively associated, while the left pallidum (t-statistic = 2.72, p = 0.02) was positively associated with cognitive scores. The efferent flow from the right amygdala (t-statistic = -2.34, p = 0.03) was negatively associated with language scores, while efferent flow from the brainstem (t-statistic = 2.38, p = 0.03) was positively associated with motor scores.

conclusionsEfferent output from specific hubs at birth is associated with neurodevelopmental outcomes at two years of age.

Indexed as

BrainChild DevelopmentChild, PreschoolCognitionElectroencephalographyFemaleHumansInfantInfant, NewbornMaleNeural PathwaysDirectional flowHD-EEG source analysisLinearly constrained minimum variance beamformerNeurodevelopmental outcome

Identifiers

PMID40889547
PMCPMC12755096

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.